bmrR
168
transcriptional activator ([wiki|MerR family]) of the [gene|ADBC0F194B601F736492E54011E0A68351B5BD39|bmr]-[gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR] operon, general stress protein
locus
BSU_24020
Molecular weight
32.43 kDa
pI
5.19
function
regulation of multidrug resistance
product
transcriptional activator ([wiki|MerR family])
essential
no
synonyms
bmrR
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4978 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,495,898 2,496,734
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The protein
Protein family
[wiki|MerR family]
[wiki|Domains]
[wiki|HTH merR-type domain] (aa 5-75) (according to UniProt)
Structure
[PDB|2BOW] (complex with effector), [PDB|1R8E] (complex with DNA), [PDB|1BOW]
[AF|P39075]
Expression and Regulation
Operons
genes
[gene|ADBC0F194B601F736492E54011E0A68351B5BD39|bmr]-[gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]
description
[Pubmed|7961792]
regulation
''[protein|search|bmrU]'': induced by stress ([protein|search|SigB]) [Pubmed|11544224]
regulatory mechanism
[protein|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]: activation, [Pubmed|7961792], in [regulon|protein:9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR regulon]
[protein|A7326377132C670B60695EFE0A652B1E4F623698|mta]: activation, [Pubmed|10200972], in [regulon|protein:A7326377132C670B60695EFE0A652B1E4F623698|mta regulon]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|11544224], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|10200972], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|88AECCE90DC0D6C92C61AB8860A31A830A8DAC42|bmrU]-[gene|ADBC0F194B601F736492E54011E0A68351B5BD39|bmr]-[gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]
description
[Pubmed|10220166]
regulation
''[protein|search|bmrU]'': induced by stress ([protein|search|SigB]) [Pubmed|11544224]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|11544224], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
Biological materials
Mutant
BKE24020 ([gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCCATCACTCCTTCTAT, downstream forward: _UP4_TAATAAAGCATAGAAAAAGA
BKK24020 ([gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCCATCACTCCTTCTAT, downstream forward: _UP4_TAATAAAGCATAGAAAAAGA
labs
[wiki|Richard Brennan], Houston, Texas, USA [http://www.mdanderson.org/departments/biochem/display.cfm?id=556ef368-6c81-4043-b74f350d41dd06cb&method=displayfull&pn=a8427ebd-d0ff-11d4-80fd00508b603a14 Homepage]
References
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Time of last update: 2024-04-16 08:33:22
Author of last update: Jstuelk