galK

galK
168

galactokinase

locus
BSU_38200
Molecular weight
43.36 kDa
pI
5.15
Protein length
Gene length
function
galactose utilization
product
galactokinase
essential
no
ec
2.7.1.6
synonyms
galK, ipa-35d

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0153 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,920,638  3,921,810
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The protein
Catalyzed reaction/ biological activity
α-D-galactose + ATP --> ADP + α-D-galactose 1-phosphate + H+ (according to UniProt)
Protein family
GHMP kinase family (together with [protein|8FA635D1915108BF29A864AF4DA28ECF633F735F|ispE] and [protein|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]) (according to UniProt)
Structure
[PDB|1PIE] (from ''Lactococcus lactis'', 43% identity, 60% similarity)\t[Pubmed|12796487]
[AF|P39574]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|36930CC6FDFCA23D43E264FEA375B78A1434E1BD|galK]-[gene|591428EA1C3D40322BB942429607AF61A90BAF41|galT]
description
[Pubmed|9353933]
regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|10666464]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
Open in new tab

[gene|36930CC6FDFCA23D43E264FEA375B78A1434E1BD|galK]→[gene|591428EA1C3D40322BB942429607AF61A90BAF41|galT]

2024-03-23 18:51:32

ghost

39

603ab561182787ccf42180f9123596253729b2eb

7EAB5E2D27A9196B25E69B42DEED4992D71587AA

genes
[gene|C3D87DAA8DB124D50D2C2B2D424C9608C0DE067F|ywcC]-[gene|FD30C4E458E63E8D6A932B351D4224F1AACD4B1B|gtcA]-[gene|36930CC6FDFCA23D43E264FEA375B78A1434E1BD|galK]-[gene|591428EA1C3D40322BB942429607AF61A90BAF41|galT]
description
[Pubmed|22383849,22893383]
regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|10666464]
Open in new tab

[gene|C3D87DAA8DB124D50D2C2B2D424C9608C0DE067F|ywcC]→[gene|591428EA1C3D40322BB942429607AF61A90BAF41|galT]

2024-03-14 22:16:15

ghost

64

2c55134f930fd735713cc2b5bc79db8a76ccbb71

EAEF4B4702CF0981CF8DC10BB149EDF4E1FB63DF

Biological materials
Mutant
BKE38200 ([gene|36930CC6FDFCA23D43E264FEA375B78A1434E1BD|galK]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38200 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTGCAATCACCTTTCTG,  downstream forward: _UP4_AGAGAACTAAAGGGGGAGTG
BKK38200 ([gene|36930CC6FDFCA23D43E264FEA375B78A1434E1BD|galK]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38200 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTGCAATCACCTTTCTG,  downstream forward: _UP4_AGAGAACTAAAGGGGGAGTG
References
9353933,10666464,22383849,22893383

36930CC6FDFCA23D43E264FEA375B78A1434E1BD

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Time of last update: 2024-03-28 09:35:57

Author of last update: Melvin.boenninger