gutB

gutB
168

D-sorbitol dehydrogenase

locus
BSU_06150
Molecular weight
38.23 kDa
pI
5.21
Protein length
Gene length
function
glucitol utilization
product
D-sorbitol dehydrogenase
essential
no
ec
1.1.1.14
synonyms
gutB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1063 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
667,466  668,527
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The protein
Catalyzed reaction/ biological activity
D-fructose + H+ + NADH --> D-sorbitol + NAD+ (according to UniProt)
NAD+ + xylitol --> D-xylulose + H+ + NADH (according to UniProt)
L-iditol + NAD+ --> H+ + L-sorbose + NADH (according to UniProt)
Protein family
[wiki|zinc-containing alcohol dehydrogenase family] (according to UniProt)
[wiki|Cofactors]
NAD+ (according to UniProt)
Structure
[PDB|1PL7] (the human enzyme, 42% identity) [pubmed|12962626]
[AF|Q06004]
Expression and Regulation
Operons
genes
[gene|2E9D10B0FA5685800007222A5AAD71E975675DB1|gutB]-[gene|B13F7C35FBD55C674E5B19836D32279E7C1A5520|gutP]-[gene|0C4F0C9EF18FB4E9BB5BC3F53F7DDF5F32B51FA5|fruC]
description
[Pubmed|22383849]
regulation
induced by glucitol ([protein|926BCA197F259558F72FDCC73998497B9B167D22|gutR]) [Pubmed|8195086]
regulatory mechanism
[protein|926BCA197F259558F72FDCC73998497B9B167D22|gutR]: activation, [Pubmed|8195086], in [regulon|protein:926BCA197F259558F72FDCC73998497B9B167D22|gutR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8195086], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|2E9D10B0FA5685800007222A5AAD71E975675DB1|gutB]→[gene|0C4F0C9EF18FB4E9BB5BC3F53F7DDF5F32B51FA5|fruC]

2024-03-18 14:15:11

Jstuelk

52

021d8d434b2f43c239e1cc155b699e0c93f8c1d8

32A5BA6116781DB64C7C35379A2BF99496685BCC

Biological materials
Mutant
BKE06150 ([gene|2E9D10B0FA5685800007222A5AAD71E975675DB1|gutB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE06150 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTGGCAAGTTCCTTTCT,  downstream forward: _UP4_TGAGTGAACAGGGAGGATCT
BKK06150 ([gene|2E9D10B0FA5685800007222A5AAD71E975675DB1|gutB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK06150 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTGGCAAGTTCCTTTCT,  downstream forward: _UP4_TGAGTGAACAGGGAGGATCT
References
1460002,12897001,8195086,12962626

2E9D10B0FA5685800007222A5AAD71E975675DB1

Page visits: 2895

Time of last update: 2024-03-28 19:52:42

Author of last update: Melvin.boenninger