minC

minC
168

cell-division inhibitor (septum placement), destabilizes Z ring placement

locus
BSU_28000
Molecular weight
24.85 kDa
pI
6.26
Protein length
Gene length
function
septum placement
product
cell-division inhibitor
essential
no
synonyms
minC

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0850 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,858,584  2,859,264
Phenotypes of a mutant
a ''[gene|1986DB3078FBA16D6ACCD70EEAC95C46564D0958|whiA] [gene|8C94C9598A823A8405B3E1FA0124E21D90845B8E|minC]-[gene|37DAD42A391E2FC506225EAF91B8F21629A401DF|minD]'' mutant grows poorly, and the cells are filamentous [Pubmed|24097947]
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The protein
Catalyzed reaction/ biological activity
The Min system prevents minicell formation adjacent to recently completed division sites by promoting the disassembly of the cytokinetic ring, thereby ensuring that cell division occurs only once per cell cycle  [Pubmed|20352045]
binds the C-terminal domain of [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ] to inhibit its polymerization [Pubmed|23577149]
Protein family
minC family (single member, according to UniProt)
Structure
[PDB|1HF2] (from ''Thermotoga maritima'', 26% identity) [Pubmed|11350934]
[AF|Q01463]
[wiki|Localization]
polar/septal at the cell membrane [Pubmed|20566861]
membrane binding/polar localization depends on the proton motive force [Pubmed|20566861]
Expression and Regulation
Operons
genes
[gene|A4C8719E06F774A6EB4D79757CC79CF89E453A54|mreB]-[gene|6A14D0C7FD94A838BAB3B74AA100EA678F1E4E34|mreC]-[gene|231C30963AFB863424C087CB722446D319976D65|mreD]-[gene|8C94C9598A823A8405B3E1FA0124E21D90845B8E|minC]-[gene|37DAD42A391E2FC506225EAF91B8F21629A401DF|minD]
description
[Pubmed|8459776]
regulation
constitutively expressed [Pubmed|23701187]
regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]: activation, [Pubmed|26091431], in [regulon|protein:08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, promoter p1, upstream of [protein|49D996C9AED44A820A214C3DF60AB1B6E1508DEA|maf] [Pubmed|26091431], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, promoter p2, within [protein|49D996C9AED44A820A214C3DF60AB1B6E1508DEA|maf] [Pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, promoter p4, upstream of [protein|8C94C9598A823A8405B3E1FA0124E21D90845B8E|minC] [Pubmed|8459776], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
Open in new tab

[gene|A4C8719E06F774A6EB4D79757CC79CF89E453A54|mreB]→[gene|37DAD42A391E2FC506225EAF91B8F21629A401DF|minD]

2024-03-27 17:23:18

ghost

97

df866addcf0a1b269336e8d5bd5fbd5f95fab5a3

37AF85C74BFE779D7BD018F30628D4588CACE9D3

genes
[gene|8C94C9598A823A8405B3E1FA0124E21D90845B8E|minC]-[gene|37DAD42A391E2FC506225EAF91B8F21629A401DF|minD]
description
[Pubmed|8459776]
regulation
constitutively expressed [Pubmed|23701187]
Open in new tab

[gene|8C94C9598A823A8405B3E1FA0124E21D90845B8E|minC]→[gene|37DAD42A391E2FC506225EAF91B8F21629A401DF|minD]

2024-03-04 09:35:20

ghost

57

3cf77b66614658eaae6b7fe62e467485f48b1db2

5296B8543F3BF57CD786DD7DA18A4244A4551659

genes
[gene|49D996C9AED44A820A214C3DF60AB1B6E1508DEA|maf]-[gene|2BD11D71AA6D9EFAD8A209C8813CC8B059180C84|radC]-[gene|A4C8719E06F774A6EB4D79757CC79CF89E453A54|mreB]-[gene|6A14D0C7FD94A838BAB3B74AA100EA678F1E4E34|mreC]-[gene|231C30963AFB863424C087CB722446D319976D65|mreD]-[gene|8C94C9598A823A8405B3E1FA0124E21D90845B8E|minC]-[gene|37DAD42A391E2FC506225EAF91B8F21629A401DF|minD]
description
[Pubmed|22383849]
regulation
constitutively expressed [Pubmed|23701187]
regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]: activation, [Pubmed|11948146,11918817,21564336], in [regulon|protein:08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK regulon]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, promoter p2 within [protein|49D996C9AED44A820A214C3DF60AB1B6E1508DEA|maf] [Pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, promoter p1, upstream of [protein|49D996C9AED44A820A214C3DF60AB1B6E1508DEA|maf] [Pubmed|26091431], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|49D996C9AED44A820A214C3DF60AB1B6E1508DEA|maf]→[gene|37DAD42A391E2FC506225EAF91B8F21629A401DF|minD]

2024-03-27 17:27:16

ghost

88

5cb36570cb9eb74ac55107ce2bd7f07e7d2d5c0b

EE31E7A5D1B0C8BDC56B004AA68A1C721D4DA9CC

Biological materials
Mutant
BSN375 (''[gene|8C94C9598A823A8405B3E1FA0124E21D90845B8E|minC]''::''aphA3'') (available in [wiki|Leendert Hamoen]'s, [wiki|Sven Halbedel]'s and [wiki|Jörg Stülke]'s labs)
BKE28000 ([gene|8C94C9598A823A8405B3E1FA0124E21D90845B8E|minC]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE28000 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACAATATTCACCTCAACAA,  downstream forward: _UP4_ACAAGGCTTGAGGGAGGAAT
BKK28000 ([gene|8C94C9598A823A8405B3E1FA0124E21D90845B8E|minC]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK28000 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACAATATTCACCTCAACAA,  downstream forward: _UP4_ACAAGGCTTGAGGGAGGAAT
two-hybrid system
''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([wiki|BACTH]), available in [wiki|Jörg Stülke]'s lab
References
Reviews
19680248,19884039,24367361,28697666,35638784
Original Publications
8459776,19019154,1400224,10411726,15317782,20352045,18588879,19141479,20566861,20711458,24097947,18179421,22457634,23577149,21926231,23701187,24366721,11350934,22383849,26091431,30092000,33686188,35495694

8C94C9598A823A8405B3E1FA0124E21D90845B8E

Page visits: 4701

Time of last update: 2024-03-27 22:15:53

Author of last update: Jstuelk