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Categories containing this gene/protein

transcription factors and their control

This gene is a member of the following regulons

The NrdR regulon


  • Coordinates on the chromosome (coding sequence): 2,965,681 -> 2,966,139
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • nrdR family (according to Swiss-Prot)
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity




    Additional information

    Expression and Regulation


  • nrdR PubMed
  • Sigma factor


  • constitutively expressed PubMed
  • Regulatory mechanism

    Additional information

  • the terminator is NusA-dependent Reference
  • Biological materials


  • MGNA-A123 (ytcG::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Castro-Cerritos KV, Yasbin RE, Robleto EA, Pedraza-Reyes M

    Role of Ribonucleotide Reductase in Bacillus subtilis Stress-Associated Mutagenesis

    J Bacteriol. 2017 Jan 30;199(4). pii: e00715-16. doi: 10.1128/JB.00715-16. Print 2017 Feb 15. PubMed PMID: 27920297; PubMed Central PMCID: PMC5287397.
    Grinberg I, Shteinberg T, Gorovitz B, Aharonowitz Y, Cohen G, Borovok I

    The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons

    J Bacteriol. 2006 Nov;188(21):7635-44. Epub 2006 Sep 1. PubMed PMID: 16950922; PubMed Central PMCID: PMC1636249.
    Rodionov DA, Gelfand MS

    Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling

    Trends Genet. 2005 Jul;21(7):385-9. PubMed PMID: 15949864.
    Lapidus A, Galleron N, Sorokin A, Ehrlich SD

    Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region

    Microbiology. 1997 Nov;143 ( Pt 11):3431-41. PubMed PMID: 9387221.
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