rsiV
168
anti-[wiki|sigma factor] to [protein|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV]
locus
BSU_27130
Molecular weight
32.72 kDa
pI
5.83
function
control of [protein|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV] activity
product
anti-[wiki|sigma factor] to [protein|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV]
essential
no
synonyms
rsiV, yrhM
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
2,770,350 → 2,771,207
Phenotypes of a mutant
the mutant tends to acquire suppressor mutations that result in improved growth [Pubmed|28189581]
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The protein
Catalyzed reaction/ biological activity
binds and thus inactivates [protein|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV]
Structure
[PDB|5JEN] (complex with lysozyme)
[AF|O05403]
Effectors of protein activity
RsiV directly binds lysozyme [Pubmed|25275625]
upon exposure to lysozyme, the extracellular domain of [protein|ED1DDA187692683D9862EC0E858B80CD56C48045|rsiV] is cleaved off by [protein|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS] and [protein|search|SipT ](between A66 and M67), subsequently the N-terminal part of the protein is subject to intramemrane proteolysis by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|rasP] [Pubmed|29358498,25275625,23687273]
[wiki|Localization]
membrane [Pubmed|23687273]
Expression and Regulation
Operons
genes
[gene|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV]-[gene|ED1DDA187692683D9862EC0E858B80CD56C48045|rsiV]-[gene|E97C7A219DB059BB634E893CC355A28324C87ADB|oatA]-[gene|FC37C7A0C0D9F50CA1D44B8D939CF06E210D4B38|yrhK]
description
[Pubmed|21856855]
regulation
induced by lysozyme ([protein|search|SigV]) [Pubmed|21856855]
sigma factors
[protein|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV]: sigma factor, [Pubmed|21856855], in [regulon|protein:D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV regulon]
additional information
A [protein|search|ncRNA] ([wiki|RnaC]) is encoded between '[protein|search|yrhK]' and '[protein|search|yrhJ]' [PubMed|25790031]
Biological materials
Mutant
MGNA-A145 (yrhM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/145 NBRP B. subtilis, Japan]
BKE27130 (Δ[gene|ED1DDA187692683D9862EC0E858B80CD56C48045|rsiV]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TAATTGCTGTAATCTCTTAT, downstream forward: _UP4_TAAAATAAAAACATCCATCT
BKK27130 (Δ[gene|ED1DDA187692683D9862EC0E858B80CD56C48045|rsiV]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TAATTGCTGTAATCTCTTAT, downstream forward: _UP4_TAAAATAAAAACATCCATCT
References
Reviews
Original Publications
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Time of last update: 2024-04-18 11:56:25
Author of last update: Christoph.elfmann