uvrA

uvrA
168

excinuclease ABC (subunit A), required for transcription-dependent asymmetry in mutation rates of genes in the two orientations

locus
BSU_35160
Molecular weight
105.83 kDa
pI
5.84
Protein length
Gene length
function
DNA repair after UV damage
product
excinuclease ABC (subunit A)
essential
no
synonyms
uvrA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0178 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,610,064  3,612,937
Phenotypes of a mutant
reduced stationary phase mutagenesis [Pubmed|27399782]
a [gene|39B73AADBFD42203ADFA2E834697799E6430A086|uvrA] [gene|DEFBDC2AB8E43FB06C65389160E8EACFE5FB9705|uvrB] mutant is sensitive to blue light-induced DNA damage [pubmed|30054368]
sensitive to Cr(VI) treatment [pubmed|30745368]
reduced resistance towards electron beams [pubmed|31948638]
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The protein
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
2 [wiki|ABC transporter domain]s (aa 309-587, aa 607-935) (according to UniProt)
Structure
[PDB|2R6F] (Geobacillus stearothermophilus)
[AF|O34863]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|DEFBDC2AB8E43FB06C65389160E8EACFE5FB9705|uvrB]-[gene|39B73AADBFD42203ADFA2E834697799E6430A086|uvrA]
description
[Pubmed|22383849]
regulation
induced upon DNA damage ([protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]) [Pubmed|8226626]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|8226626], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
additional information
during [protein|search|sporulation] expressed both in the forespore and the mother cell [PubMed|24118570]
expression is induced in the presence of Cr(VI) [pubmed|30745368]
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[gene|DEFBDC2AB8E43FB06C65389160E8EACFE5FB9705|uvrB]→[gene|39B73AADBFD42203ADFA2E834697799E6430A086|uvrA]

2024-02-12 08:23:20

Jstuelk

60

64e9c2eef7258297470790f72dba7931d9d59a23

8F26139F6B9D375FE6C35423921E79A506C28EB3

Biological materials
Mutant
GP3534 (Δ([gene|39B73AADBFD42203ADFA2E834697799E6430A086|uvrA]-[gene|DEFBDC2AB8E43FB06C65389160E8EACFE5FB9705|uvrB])::kan), available in [wiki|Jörg Stülke]'s lab
GP1175 (Δ([gene|39B73AADBFD42203ADFA2E834697799E6430A086|uvrA]-[gene|DEFBDC2AB8E43FB06C65389160E8EACFE5FB9705|uvrB])::ermC), available in [wiki|Jörg Stülke]'s lab [pubmed|22178973]
BKE35160 ([gene|39B73AADBFD42203ADFA2E834697799E6430A086|uvrA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE35160 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TATCCGATCCATAGCCATTT,  downstream forward: _UP4_TAAAACCCTCTGTTAAGAGG
BKK35160 ([gene|39B73AADBFD42203ADFA2E834697799E6430A086|uvrA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK35160 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TATCCGATCCATAGCCATTT,  downstream forward: _UP4_TAAAACCCTCTGTTAAGAGG
References
Reviews
16464004,15927210,7801120,22933559,35210609
Original Publications
11751826,21145481,8226626,24118570,25713353,27399782,30054368,30745368,31948638

39B73AADBFD42203ADFA2E834697799E6430A086

Page visits: 2187

Time of last update: 2024-03-26 01:27:37

Author of last update: Jstuelk