ltaS

ltaS
168

major polyglycerolphosphate lipoteichoic acid synthase, required for proper colony development

locus
BSU_07710
Molecular weight
74.05 kDa
pI
5.2
Protein length
Gene length
function
biosynthesis of lipoteichoic acid
product
major lipoteichoic acid synthase
essential
no
ec
2.7.8.-
synonyms
ltaS, yflE

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1368 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
842,047  843,996
Phenotypes of a mutant
induction of [protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM] and [protein|E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX] activities [Pubmed|23103977]
reduced [protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]-dependent expression of ''[gene|E8B88CBE4F9121DFEEF099D7947CD1E1AE656160|lytF]'' [Pubmed|25288647]
extended lag phase [pubmed|29114240]
reduced colony size with accumulation of dead cells in the colonies [pubmed|29114240]
suppression of the growth and morphology defects of a [gene|7150BABA5086D5E2EB8102E4901A216F43576282|glmR] mutant [pubmed|30478337]
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The protein
Protein family
[wiki|LTA synthase family] (according to UniProt)
[wiki|Cofactors]
Mn(2+) [pubmed|37794032]
Structure
[PDB|2W8D] [pubmed|19229300]
[AF|O34952]
Modification
phosphorylated on Thr-297 [Pubmed|19229300]
can be phosphorylated by [protein|23FF4A00C36EC1B7297F51A9EF3579B41F0B7EBA|prkC] in vitro [pubmed|30478337]
Paralogous protein(s)
[protein|880C655DC7149F6EDC21BD2CF8F9F2C9FBEB2CDB|yvgJ], [protein|CCD06F344E3C87E77C3D13883CE2B927F372A84E|yfnI], [protein|2B33F2F9C2FB0767B72A29D060037393C88ACEE5|yqgS]
[wiki|Localization]
cell membrane, at the septum of the cell  [Pubmed|15743965]
extracellular (signal peptide) [Pubmed|18957862]
Expression and Regulation
Operons
genes
[gene|418900B6DBDF3EF300C930B0C75E31B939F3CE00|ltaS]
description
[pubmed|22383849]
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[gene|418900B6DBDF3EF300C930B0C75E31B939F3CE00|ltaS]

2024-03-10 09:02:07

Jstuelk

56

7b40aa8792391f2111f03c85776e8ccbba26ff09

FB295BD036D4966DA73D641F0730F8F3BA7131D4

Biological materials
Mutant
MGNA-C256 (yflE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2254 NBRP B. subtilis, Japan]
GP1389 ''ltaS::aphA3'', available in [wiki|Jörg Stülke]'s lab
GP1396 ''ltaS::tet'', available in [wiki|Jörg Stülke]'s lab
BKE07710 ([gene|418900B6DBDF3EF300C930B0C75E31B939F3CE00|ltaS]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE07710 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGTTACACTCCTTTTTT,  downstream forward: _UP4_TAAGAAAAAGCGGAGAGGTT
BKK07710 ([gene|418900B6DBDF3EF300C930B0C75E31B939F3CE00|ltaS]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK07710 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGTTACACTCCTTTTTT,  downstream forward: _UP4_TAAGAAAAAGCGGAGAGGTT
References
Reviews
21388439,21255102,24819367
Original Publications
19229300,17483484,21255105,19168632,15743965,23103977,25288647,29114240,30478337,36744964,37794032

418900B6DBDF3EF300C930B0C75E31B939F3CE00

Page visits: 5112

Time of last update: 2024-03-28 13:03:41

Author of last update: Jstuelk