yhdR
168
similar to aspartate aminotransferase
locus
BSU_09570
Molecular weight
43.73 kDa
pI
5.01
function
unknown
product
unknown
essential
no
ec
2.6.1.1
synonyms
yhdR
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0436 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,034,046 1,035,227
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The protein
Catalyzed reaction/ biological activity
2-oxoglutarate + L-aspartate --> L-glutamate + oxaloacetate (according to UniProt), this activity is rather unlikely as the [gene|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB] mutant is auxotrophic for aspartate indicating that [protein|8F7432F7EF0F767C6000D553A3ACE29FBA2EDCEE|yhdR] does not contribute to aspartate synthesis [pubmed|29995990]
Protein family
[wiki|class-I pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
[wiki|Cofactors]
PLP
Structure
[PDB|3ELE] (from Eubacterium rectale, 34% identity)
[AF|O07587]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
The gene is annotated in KEGG as aspartate aminotransferase EC 2.6.1.1. In MetaCyc the protein is marked as similar to aspartate aminotransferase. No EC annotation is available in Swiss-Prot. No literature/experimental evidence supporting the annotation is availablavailable. [Pubmed|19935659]
Expression and Regulation
Operons
genes
[gene|8F7432F7EF0F767C6000D553A3ACE29FBA2EDCEE|yhdR]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-B485 (yhdR::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1484 NBRP B. subtilis, Japan]
BKE09570 ([gene|8F7432F7EF0F767C6000D553A3ACE29FBA2EDCEE|yhdR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE09570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGTCCCTTCCGCATAT, downstream forward: _UP4_TAAGAAGGCAAAGAAAAGAA
BKK09570 ([gene|8F7432F7EF0F767C6000D553A3ACE29FBA2EDCEE|yhdR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK09570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGTCCCTTCCGCATAT, downstream forward: _UP4_TAAGAAGGCAAAGAAAAGAA
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Time of last update: 2024-04-15 17:37:25
Author of last update: Jstuelk