trmR

trmR
168

tRNA wobble uridine modifying methyltransferase

locus
BSU_27360
Molecular weight
24.92 kDa
pI
5.57
Protein length
Gene length
function
introduction of 5-methoxyuridine modification in tRNA (U34)
product
tRNA wobble uridine modifying methyltransferase
essential
no
synonyms
trmR, yrrM

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4122 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,795,082 → 2,795,735
Visit Sartorius.com Visit Sartorius.com
Advertisement
The protein
Catalyzed reaction/ biological activity
methylation of (5-hydroxyuridine) ho5U containing tRNA to 5-methoxyuridine (mo5U) [pubmed|29982645]
5-hydroxyuridine34 in tRNA + S-adenosyl-L-methionine --> 5-methoxyuridine34 in tRNA + H+ + S-adenosyl-L-homocysteine (according to UniProt)
Protein family
[wiki|Methyltransferase superfamily] (according to UniProt)
[wiki|class I-like SAM-binding methyltransferase superfamily] (according to UniProt)
[wiki|Cofactors]
SAM [pubmed|29982645]
Structure
[PDB|5ZW3] [pubmed|29982645]
[PDB|5ZW4] (bound to tRNA) [pubmed|29982645]
[AF|O32036]
Expression and Regulation
Operons
genes
[gene|CE4F2965077F2A5882432D683520E09B70B9369A|trmR]-[gene|A3EC327DA14F188E88AF4221B51EE5950F882277|yrrN]-[gene|D4046AA4C4ACB6A0A2F2020CA1E659F65CAFE68D|yrrO]-[gene|A659D9894E777D8A99707CB750DF2918AEE06CE9|udk]-[gene|6FBF27C12B4B3DC2CE373E5199357042114471F8|greA]
description
[Pubmed|22383849]
Open in new tab

[gene|CE4F2965077F2A5882432D683520E09B70B9369A|trmR]→[gene|6FBF27C12B4B3DC2CE373E5199357042114471F8|greA]

2024-03-21 13:39:38

Jstuelk

142

0a66c040f2f5a1d47c0559c4047af2666d30c835

5807E821D8403F7EC565573C8910C732811F8BB4

Biological materials
Mutant
MGNA-A853 (yrrM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/853 NBRP B. subtilis, Japan]
BKE27360 (Δ[gene|CE4F2965077F2A5882432D683520E09B70B9369A|trmR]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27360 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACTACAAACAGCCTCCCGT,  downstream forward: _UP4_AGTAAAAAGAAGAGGTGAAC
BKK27360 (Δ[gene|CE4F2965077F2A5882432D683520E09B70B9369A|trmR]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27360 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACTACAAACAGCCTCCCGT,  downstream forward: _UP4_AGTAAAAAGAAGAGGTGAAC
References
Research papers
29982645,31358606

CE4F2965077F2A5882432D683520E09B70B9369A

Page visits: 1567

Time of last update: 2024-03-28 04:13:54

Author of last update: Melvin.boenninger