indole-3-glycerol-phosphate synthase
function
biosynthesis of tryptophan
product
indole-3-glycerol-phosphate synthase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]This gene is a member of the following [SW|regulons]
[SW|TRAP regulon]The protein
Catalyzed reaction/ biological activity
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate CO2 H2O (according to Swiss-Prot)Structure
[PDB|1VC4] (from ''Thermus thermophilus'', 36% identity, 49% similarity)Expression and Regulation
Operon
''[protein|search|aroF]-[protein|search|aroB]-[protein|search|aroH]-[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])''[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' [Pubmed|3924737][SW|Sigma factor]
''[protein|search|trpE]'': [protein|search|SigA] [Pubmed|6436812]Regulation
not expressed if tryptophan is available ([MtrB|search|TRAP]) [Pubmed|1551827]Regulatory mechanism
[MtrB|search|TRAP]: binding to the mRNA in the presence of tryptophan, this results in transcription termination [Pubmed|8419914]References
14976255,3924737,6436812,2422155,8419914,1551827,21815947 
