ywcE [Mon Aug 31 2015 13:57:27 GMT+0200 (CEST)]

holin, required for spore morphogenesis and germination

locus: BSU38130

pI: 9.85

mw: 9.00 kDa

function: required for spore morphogenesis and germination

product: holin

essential: no

synonyms: ipa-41r

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.3|Sporulation/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.4|Germination] → [category|SW 4.2.4.2|Additional germination proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

syns: ipa-41r

[SW|Categories] containing this gene/protein

• [SW|sporulation/ other], [SW|germination], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon]

The protein

Protein family

• ywcE family (according to Swiss-Prot)

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''ywcE'' [Pubmed|9353933]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|16159778]

Regulation

• repressed during the log phase ([protein|search|AbrB]), expressed only at the onset of stationary phase [Pubmed|16159778]
• strongly induced in response to glucose starvation in M9 medium [Pubmed|23033921]

Regulatory mechanism

• [protein|search|AbrB]: transcription repression [Pubmed|16159778]

Labs working on this gene/protein

• [SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]

References

• 16159778,9353933,23033921