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parE
subunit of DNA topoisomerase IV
function
chromosome segregation and compaction
product
subunit of DNA topoisomerase IV
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]Gene
Coordinates
1,933,477 → 1,935,444
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Protein family
type IIA topoisomerase family (according to Swiss-Prot)Paralogous protein(s)
[protein|AA42910B71348EFEA4165CFFCEF1E497897B9DDC|GyrB] [SW|Domains]
[SW|TOPRIM domain] (aa 423-537) [Pubmed|9722641]Structure
[PDB|4I3H] (from ''Streptococcus pneumoniae'', 70% identity) [Pubmed|23965305][SW|Localization]
Nucleoid (Homogeneous) [Pubmed|16479537]uniformly distributed throughout the cell [Pubmed|9539793]Expression and Regulation
Operons
genes
[gene|1901C52DCB24B3D53150F6926C14907AC1B75293|parE]-[gene|9075DD0CC0B8554F0379732453665F43C70EFC26|parC]
description
[Pubmed|16267290]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]: repression, [Pubmed|16267290], in [regulon|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA regulon]regulation
induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]additional information
term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''parE'' [Pubmed|27120414]view in new tabBiological materials
lacZ fusion
GP2550 ([gene|1901C52DCB24B3D53150F6926C14907AC1B75293|parE]::lacZ cat, based on [SW|pAC5]), available in [SW|Jörg Stülke]'s labReferences
Reviews
Original publications
16272394,9539793,16267290,16479537,23965305,27120414,9722641,12767818,10713132,9334322,8940171,7590259,10944214,1330320,12857958,11090135,8104339,8227000 
