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comGC [Mon May 16 2016 17:40:39 GMT+0200 (CEST)]
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comGC [Mon May 16 2016 17:40:39 GMT+0200 (CEST)]

DNA uptake, major component of the pseudopilus
locus
BSU24710
pI
6.00
mw
10.00 kDa
function
genetic competence
product
major pseudopilin
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|genetic competence], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|ComK regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,557,673 -> 2,557,969

    Phenotypes of a mutant

  • knockout has complete loss of transformation competence [Pubmed|1968455]
  • The protein

    Protein family

  • comGC family (according to Swiss-Prot)
  • [SW|Localization]

  • cell surface [Pubmed|9723928]
  • localizes to the cell membrane and the cytoplasm [Pubmed|21278288]
  • localizes to one single cell pole in the majority of the cells [Pubmed|21278288]
  • [SW|Interactions]

  • [SW|ComGB]-[SW|ComGC] [Pubmed|15083159]
  • [protein|search|ComC]-[SW|ComGC] [Pubmed|9723928]
  • forms large complexes (the [SW|pseudopilus]) [Pubmed|21278288]
  • Expression and Regulation

    Operon

  • ''[SW|comGA]-[SW|comGB]-[SW|comGC]-[SW|comGD]-[SW|comGE]-[SW|comGF]-[SW|comGG]-[protein|search|spoIIIL]'' [Pubmed|2507524]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|2507524]
  • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • Regulatory mechanism

  • [protein|search|ComK]: transcription activation [Pubmed|8196543]
  • References

    Reviews

  • 15083159
  • Original publications

  • 11744713,11814663,9422590,16751195,9723928,1968455,7783624,21278288,12107147,2507524,8196543