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sunA [Sun Dec 04 2016 12:34:55 GMT+0100 (CET)]
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sunA [Sun Dec 04 2016 12:34:55 GMT+0100 (CET)]

sublancin 168 lantibiotic antimicrobial precursor peptide
locus
BSU21480
pI
7.00
mw
5.00 kDa
function
antimicrobial peptide
product
sublancin 168 lantibiotic antimicrobial precursor peptide
essential
no
synonyms
yolG
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.3|Toxins, antitoxins and immunity/ Additional genes]
  • [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.2|SP-beta prophage]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds], [SW|toxins, antitoxins and immunity against toxins], [SW|SP-beta prophage], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|Abh regulon], [SW|AbrB regulon], [SW|Rok regulon], [SW|YvrHb regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,269,521 -> 2,269,691

    The protein

    Protein family

  • IPP isomerase type 2 family (according to Swiss-Prot)

    • Modification

  • contains a glucose attached to a cysteine residue, glycosylation is essential for its antimicrobial activity [Pubmed|21196935]

    • Structure

  • [PDB|2MIJ] [Pubmed|24405370]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''sunA'' [Pubmed|16306698]
  • ''[SW|sunA]-[SW|sunT]-[SW|bdbA]-[SW|yolJ]-[SW|bdbB]'' [Pubmed|22383849]

    • Regulation

  • repressed by [protein|search|Rok]-[SW|DnaA] [Pubmed|27902860,15743949]
  • repressed during logrithmic growth ([protein|search|AbrB]) [Pubmed|17720793]

    • Regulatory mechanism

  • activated by [SW|YvrHb] [Pubmed|16306698]
  • [protein|search|Rok]-[SW|DnaA]: transcription repression [Pubmed|27902860,15743949]
  • [protein|search|AbrB]: transcription repression[Pubmed|20817675,17720793]
  • [protein|search|Abh]: transcription activation [Pubmed|20817675,19465659]

    • Additional information

  • the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]

    • Biological materials

    Mutant

  • GP1563 (aphA3), available in [SW| Jörg Stülke]'s lab
  • GP1565 (''[protein|search|sunA]-[protein|search|sunI]'', aphA3), available in [SW| Jörg Stülke]'s lab

    • References

  • 27902860,12884008,9722542,15743949,17720793,16306698,19465659,21196935,24405370,22400495,20817675,21196935,21910430,25879813,26282429,26339632