SubtiBank SubtiBank
trxB
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trxB

thioredoxin reductase (NADPH)
locus
BSU_34790
pI
4.99
mw
34.36 kDa
protein length
316 aa Sequence Blast
gene length
951 bp Sequence Blast
function
keeps [protein|4E5C84FDC8FE2FEFF47306C91ECAB7F17D3E38E9|thioredoxin] in the reduced state
product
thioredoxin reductase (NADPH)
essential
yes
ec
1.8.1.9
synonyms
yvcH,trxR

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.3|Electron transport/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    3,573,207 3,574,157

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • [protein|4E5C84FDC8FE2FEFF47306C91ECAB7F17D3E38E9|Thioredoxin] + NADP+ --> [protein|4E5C84FDC8FE2FEFF47306C91ECAB7F17D3E38E9|thioredoxin] disulfide + NADPH [pubmed|30855939]
  • Protein family

  • class-II pyridine nucleotide-disulfide oxidoreductase family (with [protein|8F23B575BC32EA63267C4321DD8E4BD546B11AF1|AhpF], according to UniProt)
  • [SW|Cofactors]

  • FAD [Pubmed|30855939]
  • Structure

  • [PDB|4GCM] (from ''S. aureus, 71% identity'')
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    genes
    [gene|1BC439BBCD5FE19D5780519D7E4317C2EFF0D21B|trxB]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]: activation, [Pubmed|29271514,12642660], in [regulon|2C6386E9A63F410558D168798D077DF91590F454|Spx regulon]
  • regulation

  • induced by cell wall stress ([protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]) [pubmed|29271514]
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    References

    Reviews

  • 23899494
  • Original publications

  • 20084284,12642660,20525796,24401092,29271514,30855939