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resD [Sun Nov 27 2016 18:16:17 GMT+0100 (CET)]
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resD [Sun Nov 27 2016 18:16:17 GMT+0100 (CET)]

two-component response regulator (OmpR family), regulation of aerobic and anaerobic respiration, activates expression of target genes in response to oxygen limitation
locus
BSU23120
pI
5.00
mw
27.00 kDa
function
regulation of aerobic and anaerobic respiration
respiration
product
two-component response regulator (OmpR family)
essential
no
synonyms
ypxD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.1|Regulators of electron transport]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]

    • [SW|Categories] containing this gene/protein

  • [SW|regulators of electron transport], [SW|transcription factors and their control], [SW|membrane proteins], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon], [SW|PhoP regulon], [SW|ResD regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,417,181 -> 2,417,903

    The protein

    Protein family

  • [SW|OmpR family] of two-component response regulators

    • Modification

  • phosphorylated by [protein|search|ResE] on an Asp residue

    • Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • [SW|Interactions]

  • ResD interacts with the [SW|RNA polymerase] [Pubmed|21710567]
  • [protein|search|ResE]-[protein|search|ResD]

    • Expression and Regulation

    [SW|Sigma factor]

  • ''[protein|search|resA]'': [protein|search|SigA] [Pubmed|8631715]
  • ''[protein|search|resD]'': [protein|search|SigA] [Pubmed|8631715]

    • Regulation

  • expressed under anaerobic conditions ([protein|search|ResD]) [PubMed|8631715,11222591]
  • expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|9988472]
  • repressed by glucose ([protein|search|CcpA]) [Pubmed|16825793]
  • induced by daptomycin [Pubmed|27791134]

    • Regulatory mechanism

  • [protein|search|ResD]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
  • [protein|search|PhoP]: transcription activation [Pubmed|9988472]
  • [protein|search|CcpA]: transcription repression [Pubmed|16825793]

    • Labs working on this gene/protein

  • [SW|Marion Hulett], University of Illinois at Chicago, USA [http://www.uic.edu/depts/bios/faculty/hulett/hulettm.shtml Homepage]

    • References

    Reviews

  • 23046954

    • Original publications

  • 8682783,15576792,16885274,16885456,11325953,10094672,17322317,8631715,9988472,10972837,10972836,9352926,16825793,8631715,11222591,9988472,21091510,22287527,21710567,24214949,27791134