SubtiBank SubtiBank
nadF
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nadF

NAD kinase
locus
BSU11610
pI
5.99
mw
29.86 kDa
protein length
266 aa Sequence Blast
gene length
798 bp Sequence Blast
function
generation of NADP from NAD
product
inorganic polyphosphate/ATP-NAD kinase
essential
yes
ec
2.7.1.23
synonyms
yjbN, ppnK
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    1,237,660 → 1,238,460

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + NAD+ = ADP + NADP+ (according to Swiss-Prot)

    • Protein family

  • NAD kinase family (according to Swiss-Prot)

    • Effectors of protein activity

  • allosterically activated by quinolinic acid

    • Structure

  • [PDB|2I1W] (from ''Listeria monocytogenes'', 60% identity) [Pubmed|17686780]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|E5A57660B69F9E9BC52FD9C8A5E3C8786CE96728|yjbL]-[gene|81BCF5C08EC1A580F5E05884BA830130FC7E46E9|sasB]-[gene|2A2640A0501ECEA44A3C0C4842FAC053FB422A1F|nadF]-[gene|2AECDA9C4D0E704976B9E2168722EC80FE7A256D|yjbO]
    description
    [Pubmed|18067544]

    regulation

  • expressed during exponential growth
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    Biological materials

    Mutant

  • MGNA-B160 (yjbN::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1159 NBRP B. subtilis, Japan]
  • 1A825 ( ''nadF''::''erm''), [Pubmed|12682299], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A825&Search=1A825 BGSC]

    • References

  • 12897004,18067544,17686780