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dnaB

initiation of chromosome replication/ membrane attachment protein, part of the [SW|replisome]

locus: BSU_28990

pI: 5.28

mw: 54.72 kDa

protein length: 472 aa

gene length: 1419 bp

function: [category|SW 3.1.1|DNA replication]

product: helicase loader, initiation of chromosome replication/ membrane attachment protein

essential: yes

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 2,964,148 2,965,566

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• binds double-stranded DNA and co-loads the replicative helicase [pubmed|32817095]

Structure

• [PDB|5WTN] (from Geobacillus stearothermophilus, 47% identity, N-terminal domain, aa 1 - 300) [pubmed|28808061]

[SW|Localization]

• Membrane-proximal (Spotty) [Pubmed|16479537]
• forms foci, close to oriC [Pubmed|10844689]

Expression and Regulation

Operons

• genes: [gene|2AEF6D56D884CA6A0BD50FABD27F405DC2B506C7|dnaB]-[gene|AC1B507C6B1640E9BEA1F9F01628120F3680C976|dnaI]-[gene|72A4458679EA1451FA3B63D44C3BE93ACA8B397F|ytxB]-[gene|3EE0D03469D893515CAA4961BF923BE3A6769535|ytxC]-[gene|3E1131CFA3EDEB3865638F09BE2F6B6ED2570BE2|thrS]
  description: [Pubmed|22383849]

References

Reviews

• 22797751,28075389

Original publications

• 19707554,28808061,15686560,12718886,2554322,11250911,15186423,11842108,11585815,16479537,19415803,14757052,10844689,12974630,19968790,20071750,11679082,20122408,20199598,20587500,21097613,30285297,32817095