SubtiBank SubtiBank
dnaB
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dnaB

initiation of chromosome replication/ membrane attachment protein, part of the [SW|replisome]
locus
BSU_28990
pI
5.28
mw
54.72 kDa
protein length
472 aa Sequence Blast
gene length
1419 bp Sequence Blast
function
[category|SW 3.1.1|DNA replication]
product
helicase loader, initiation of chromosome replication/ membrane attachment protein
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    2,964,148 2,965,566

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • binds double-stranded DNA and co-loads the replicative helicase [pubmed|32817095]
  • Structure

  • [PDB|5WTN] (from Geobacillus stearothermophilus, 47% identity, N-terminal domain, aa 1 - 300) [pubmed|28808061]
  • [SW|Localization]

  • Membrane-proximal (Spotty) [Pubmed|16479537]
  • forms foci, close to oriC [Pubmed|10844689]
  • Expression and Regulation

    Operons

    genes
    [gene|2AEF6D56D884CA6A0BD50FABD27F405DC2B506C7|dnaB]-[gene|AC1B507C6B1640E9BEA1F9F01628120F3680C976|dnaI]-[gene|72A4458679EA1451FA3B63D44C3BE93ACA8B397F|ytxB]-[gene|3EE0D03469D893515CAA4961BF923BE3A6769535|ytxC]-[gene|3E1131CFA3EDEB3865638F09BE2F6B6ED2570BE2|thrS]
    description
    [Pubmed|22383849]
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    References

    Reviews

  • 22797751,28075389
  • Original publications

  • 19707554,28808061,15686560,12718886,2554322,11250911,15186423,11842108,11585815,16479537,19415803,14757052,10844689,12974630,19968790,20071750,11679082,20122408,20199598,20587500,21097613,30285297,32817095