SubtiBank SubtiBank
aspS
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aspS

aspartyl-tRNA synthetase
locus
BSU27550
pI
4.65
mw
65.80 kDa
protein length
592 aa Sequence Blast
gene length
1776 bp Sequence Blast
function
translation
product
aspartyl-tRNA synthetase
essential
yes
ec
6.1.1.12
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue]
  • Gene

    Coordinates
    2,814,743 → 2,816,521

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp) (according to Swiss-Prot)
  • Protein family

  • class-II aminoacyl-tRNA synthetase family (according to Swiss-Prot)
  • Modification

  • phosphorylated on ser/ thr/ tyr [Pubmed|16493705]
  • Structure

  • [PDB|1EQR] (from ''Escherichia coli'', 52% identity, 68% similarity) [Pubmed|10873442]
  • additional information

  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
  • Expression and Regulation

    Operons

    genes
    [gene|69C7EF7E76821FF3D9E866838B24C3866CA9C189|hisS]-[gene|2B61D17950ADE0247B0CF4AE33548E15C0DDCD9B|aspS]

    regulatory mechanism

  • [regulon|T-box|T-box]: transcriptional antitermination, via tRNA controlled [SW|RNA switch], in [regulon|T-box|T-box]
  • regulation

  • induced by histidine or aspartate limitation ([SW|T-box]) [Pubmed|19258532]
  • the [SW|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
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    References

  • 19258532,15378759,16493705,26804570