pgsA

phosphatidylglycerophosphate synthase

locus: BSU_16920

pI: 5.16

mw: 21.16 kDa

protein length: 193 aa

gene length: 582 bp

function: biosynthesis of phospholipids

product: phosphatidylglycerophosphate synthase

essential: yes

ec: 2.7.8.5

synonyms: ymfN

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 1,762,623 1,763,204

Phenotypes of a mutant

• some point mutations resulting in reduced PgsA activity lead to daptomycin resistance [Pubmed|21709092]essential [Pubmed|12682299]
• depletion leads to hypersensitivity to sorbic acid stress [Pubmed|27818647]

The protein

Catalyzed reaction/ biological activity

• CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate --> 1,2-diacyl-sn-glycero-3-phospho-(1ʼ-sn-glycero-3ʼ-phosphate) + CMP + H⁺ (according to UniProt)

Protein family

• CDP-alcohol phosphatidyltransferase class-I family (with [protein|DE49797486CEC172F912D26A6BF2223190BF5DAD|PssA], according to UniProt)

[SW|Localization]

• cell membrane at the septum [Pubmed|19820159,15743965]

Biological materials

Mutant

• 1A815 ( ''pgsA''::''erm''), [Pubmed|12682299], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A815&Search=1A815 BGSC]

References

• 19745567,16514141,19820159,15743965,21709092,27818647