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ydaD
general stress protein, similar to alcohol dehydrogenase
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][category|SW 6|Groups of genes] → [category|SW 6.6|Poorly characterized/ putative enzymes]Gene
Coordinates
471,709 472,569
The protein
Protein family
[SW|Short-chain dehydrogenases/reductases (SDR) family] (according to UniProt)Paralogous protein(s)
[protein|EAEEA4DD9641919830A81185333A2610B964D37C|YhdF], [protein|20A7DBA142F3BF8DCAD9732BD908CE8CC79AA993|BacC][protein|439B468A13137000FB42E9389391CB4986FFED84|FabG]: [protein|4DEFC2998464BF8327578C36A13A10DD277F991E|YkvO]: [protein|6047F2493FCE3D2A9BDB1AD88E5926ECEED81036|YhxC]: [protein|739B228743BC1FE9E6888E999BC0E4F615E36F9E|YhxD]: [protein|B6FF689E65906186F3576B378650D713DB84EDDA|YcdF]: [protein|CA4597C6253CCF7D7954686A30AF041808BDF8E5|Gdh]: [protein|D9D1FCBFC62F93CAA34DF61A784406F4E9EE6768|YjdA]: [protein|FBBDE1E058223D5E8CEB07CAA50940A329C809E4|KduD]: [protein|20A7DBA142F3BF8DCAD9732BD908CE8CC79AA993|BacC] (34.3%), [protein|439B468A13137000FB42E9389391CB4986FFED84|FabG] (31.1%), [protein|FBBDE1E058223D5E8CEB07CAA50940A329C809E4|KduD] (36.7%), [protein|EAEEA4DD9641919830A81185333A2610B964D37C|YhdF] Structure
[PDB|3I30] (from ''Bacillus Anthracis'', 61% identity)Expression and Regulation
Operons
genes
[gene|3161519994609DA9360ED6E073E4A4C8C6210EFB|ydaD]-[gene|DDE975DA2E13759B0DB8B6D219760C2E2C6032FB|ydaE]
description
[Pubmed|22383849]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [pubmed|15805528,10220166], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]regulation
induced by stress ([protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]) [Pubmed|15805528]view in new tabgenes
[gene|3161519994609DA9360ED6E073E4A4C8C6210EFB|ydaD]-[gene|DDE975DA2E13759B0DB8B6D219760C2E2C6032FB|ydaE]-[gene|BFDAB855DC76A78C100DC5E5FB81F73069F5F93F|ydaF]-[gene|29342783A375260C5DAE920FBF6EC6EFD2D54DDE|ydaG]
description
[Pubmed|10220166]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|15805528,10220166], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]regulation
induced by stress ([protein|search|SigB]) [Pubmed|15805528]view in new tabBiological materials
Mutant
MGNA-C086 (ydaD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2084 NBRP B. subtilis, Japan]BKE04190 ([gene|3161519994609DA9360ED6E073E4A4C8C6210EFB|ydaD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE04190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATGATTCTCCTCCTTT, downstream forward: _UP4_ACGACATAAGAGGGAGTGAGBKK04190 ([gene|3161519994609DA9360ED6E073E4A4C8C6210EFB|ydaD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK04190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATGATTCTCCTCCTTT, downstream forward: _UP4_ACGACATAAGAGGGAGTGAGReferences
10220166,15805528,23033921