SubtiBank SubtiBank
yjmC [2017-03-01 14:18:47]
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yjmC [2017-03-01 14:18:47]

similar to hydroxycarboxylic acid dehydrogenase, may be involved in galacturonate utilization
locus
BSU12320
pI
5.67
mw
36.00 kDa
protein length
337 aa Sequence Blast
gene length
1011 bp Sequence Blast
function
unknown
product
unknown
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon], [SW|ExuR regulon], [SW|SigE regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,303,423 -> 1,304,436

    The protein

    Protein family

  • LDH2/MDH2 oxidoreductase family (according to Swiss-Prot)
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Additional information

  • The gene is annotated in KEGG as an ortholog of malate dehydrogenase EC 1.1.1.37. but it is marked as “uncharacterized oxidoreductase” (EC 1.1.1.-) in Swiss-Prot. In MetaCyc it is marked as “similar to malate dehydrogenase”. As the paper by Mekjian et al. [Pubmed|9882655] suggests this gene is more likely to be involved in the glucuronate pathway (for which EC 1.1.1.37 is not a member), no literature/experimental evidence supporting the annotation is available. [Pubmed|19935659]
  • Expression and Regulation
    [[this]]

    Biological materials

    Mutant

  • MGNA-A367 (yjmC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/367 NBRP B. subtilis, Japan]
  • References

  • 9579062,9882655,10666464,19935659