SubtiBank SubtiBank
yjmC [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]
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yjmC [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

unknown, may be involved in galacturonate utilization
locus
BSU12320
pI
5.67
mw
36.00 kDa
function
unknown
product
unknown
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [SW|Categories] containing this gene/protein

  • [SW|utilization of specific carbon sources], [SW|sporulation proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon], [SW|ExuR regulon], [SW|SigE regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,303,423 -> 1,304,436

    The protein

    Protein family

  • LDH2/MDH2 oxidoreductase family (according to Swiss-Prot)
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Additional information

  • The gene is annotated in KEGG as an ortholog of malate dehydrogenase EC 1.1.1.37. but it is marked as “uncharacterized oxidoreductase” (EC 1.1.1.-) in Swiss-Prot. In MetaCyc it is marked as “similar to malate dehydrogenase”. As the paper by Mekjian et al. [Pubmed|9882655] suggests this gene is more likely to be involved in the glucuronate pathway (for which EC 1.1.1.37 is not a member), no literature/experimental evidence supporting the annotation is available. [Pubmed|19935659]
  • Expression and Regulation

    Operon

  • ''[protein|search|uxaC]-[protein|search|yjmB]-[protein|search|yjmC]-[protein|search|yjmD]-[protein|search|uxuA]-[protein|search|yjmF]-[protein|search|exuT]-[protein|search|exuR]-[protein|search|uxaB]-[protein|search|uxaA]'' [Pubmed|9882655]
  • ''[protein|search|yjmC]-[protein|search|yjmD]-[protein|search|uxuA]-[protein|search|yjmF]-[protein|search|exuT]-[protein|search|exuR]-[protein|search|uxaB]-[protein|search|uxaA]'' [Pubmed|9882655]
  • [SW|Sigma factor]

  • [protein|search|SigE] [Pubmed|15699190]
  • ''[protein|search|uxaC]'': [protein|search|SigA] [Pubmed|9882655]
  • ''[protein|search|yjmC]'': [protein|search|SigE] [Pubmed|9882655]
  • Regulation

  • repressed by glucose ([protein|search|CcpA]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2]
  • induced by galacturonate ([protein|search|ExuR]) [Pubmed|9882655]
  • Regulatory mechanism

  • [protein|search|CcpA]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2]
  • [protein|search|ExuR]: reanscription repression in the absence of inducer [Pubmed|9882655]
  • References

  • 9579062,9882655,10666464,19935659