unknown, may be involved in galacturonate utilization
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|ExuR regulon], [SW|SigE regulon]Gene
Coordinates on the chromosome (coding sequence)
1,303,423 -> 1,304,436
The protein
Protein family
LDH2/MDH2 oxidoreductase family (according to Swiss-Prot)[SW|Localization]
cytoplasm (according to Swiss-Prot)Additional information
The gene is annotated in KEGG as an ortholog of malate dehydrogenase EC 1.1.1.37. but it is marked as “uncharacterized oxidoreductase” (EC 1.1.1.-) in Swiss-Prot. In MetaCyc it is marked as “similar to malate dehydrogenase”. As the paper by Mekjian et al. [Pubmed|9882655] suggests this gene is more likely to be involved in the glucuronate pathway (for which EC 1.1.1.37 is not a member), no literature/experimental evidence supporting the annotation is available. [Pubmed|19935659]Expression and Regulation
Operon
''[protein|search|uxaC]-[protein|search|yjmB]-[protein|search|yjmC]-[protein|search|yjmD]-[protein|search|uxuA]-[protein|search|yjmF]-[protein|search|exuT]-[protein|search|exuR]-[protein|search|uxaB]-[protein|search|uxaA]'' [Pubmed|9882655]''[protein|search|yjmC]-[protein|search|yjmD]-[protein|search|uxuA]-[protein|search|yjmF]-[protein|search|exuT]-[protein|search|exuR]-[protein|search|uxaB]-[protein|search|uxaA]'' [Pubmed|9882655][SW|Sigma factor]
[protein|search|SigE] [Pubmed|15699190]''[protein|search|uxaC]'': [protein|search|SigA] [Pubmed|9882655]''[protein|search|yjmC]'': [protein|search|SigE] [Pubmed|9882655]Regulation
repressed by glucose ([protein|search|CcpA]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2]induced by galacturonate ([protein|search|ExuR]) [Pubmed|9882655]Regulatory mechanism
[protein|search|CcpA]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2][protein|search|ExuR]: reanscription repression in the absence of inducer [Pubmed|9882655]References
9579062,9882655,10666464,19935659 
