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srfAB [Mon Aug 31 2015 13:52:25 GMT+0200 (CEST)]
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srfAB [Mon Aug 31 2015 13:52:25 GMT+0200 (CEST)]

surfactin synthetase / competence
locus
BSU03490
pI
4.90
mw
400.00 kDa
function
antibiotic synthesis
product
surfactin synthetase / competence
essential
no
synonyms
comL
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.4|Swarming]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
    • syns
    comL

    [SW|Categories] containing this gene/protein

  • [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds], [SW|membrane proteins], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|Abh regulon], [SW|CodY regulon], [SW|ComA regulon], [SW|PerR regulon], [SW|Spx regulon]

    • The protein

    Protein family

  • ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)

    • Modification

  • phosphorylation on Ser-999 AND Ser-2045 [Pubmed|17218307]
  • phosphorylated on Arg-1378 [Pubmed|22517742]

    • [SW|Localization]

  • membrane [Pubmed|18763711]

    • Expression and Regulation

    Operon

  • ''[SW|srfAA]-[SW|srfAB]-[protein|search|comS]-[SW|srfAC]-[SW|srfAD]'' [Pubmed|1715856]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1715856]

    • Regulation

  • repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8830686]
  • repressed during hydrogen peroxide stress ([protein|search|PerR]) [Pubmed|16166527]
  • expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]

    • Regulatory mechanism

  • [protein|search|CodY]: transcription repression [Pubmed|8830686]
  • [protein|search|ComA]: transcription activation [Pubmed|1715856,16091051]
  • [protein|search|PerR]: transcription activation [Pubmed|16166527]
  • [protein|search|Spx]: transcription repression [Pubmed|12642660]
  • [protein|search|Abh]: transcription repression[Pubmed|20817675]

    • References

    Reviews

  • 20735481

    • Original publications

  • 17227471,16166527,8288534,10960106,12642660,8830686,18763711,17218307,17190806,1715856,16091051,22517742,8355610,22511326,20817675