ywhA

similar to transcriptional regulator ([SW|MarR family])

locus: BSU_37550

pI: 8.14

mw: 15.73 kDa

protein length: 139 aa

gene length: 420 bp

function: unknown

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.6|Transcription factor/ other/ based on similarity]

Gene

Coordinates: 3,853,717 3,854,136

The protein

[SW|Domains]

• [SW|HTH marR-type domain] (aa 8-139) (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|CA74CB721842927F67FBC3B5C27D2EE46B30CE1C|thrZ]-[gene|4A3CA47533B217F595E7B600923DA31228B94DA8|ywhA]
  description: [Pubmed|1379177]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1379177], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [regulon|T-box|T-box]: anti-termination, in [regulon|T-box|T-box]

  regulation

  • induced by threonine limitation ([SW|T-box]) [Pubmed|19258532]
  • the [SW|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]

Biological materials

Mutant

• MGNA-A517 (ywhA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/517 NBRP B. subtilis, Japan]
• BKE37550 ([gene|4A3CA47533B217F595E7B600923DA31228B94DA8|ywhA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE37550 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCAATTTCCCCATTTC, downstream forward: _UP4_TAGGGATAATAAAAGCCGGT
• BKK37550 ([gene|4A3CA47533B217F595E7B600923DA31228B94DA8|ywhA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK37550 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCAATTTCCCCATTTC, downstream forward: _UP4_TAGGGATAATAAAAGCCGGT

References

• 1379177,19258532