transcriptional activator of the ptb-bcd-buk-lpdV-bkdAA-bkdAB-bkdB operon
function
regulation of branched-chain amino acid utilization,
product
transcriptional activator (for SigL-dependent promoter))
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.9|Utilization of branched-chain amino acids][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|utilization of amino acids], [SW|transcription factors and their control], [SW|Transcription factors activating transcription at SigL-dependent promoters]This gene is a member of the following [SW|regulons]
[SW|CodY regulon]Gene
Coordinates on the chromosome (coding sequence)
2,504,789 -> 2,506,867
Phenotypes of a mutant
The mutant is cold-sensitive [http://www.ncbi.nlm.nih.gov/sites/entrez/16585774 PubMed]The protein
Protein family
[SW|Transcription factors activating transcription at SigL-dependent promoters][SW|Domains]
[SW|PAS domain][SW|Interactions]
[protein|search|BkdR]-[protein|search|SigL] (activation)Expression and Regulation
Operon
''bkdR'' [Pubmed|12823818]Regulation
repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|10094682]Regulatory mechanism
[protein|search|CodY]: transcription repression [Pubmed|10094682]Biological materials
Mutant
1A913 ( ''bkdR''::''kan''), [Pubmed|16585774], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A913&Search=1A913 BGSC] and in [SW|Jörg Stülke]'s labReferences
16585774,10094682,23123912,12823818,21906631 
