cssS [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

two-component sensor kinase, control of cellular responses to protein secretion stress

locus: BSU33020

pI: 5.00

mw: 51.00 kDa

function: control of cellular responses to protein secretion stress

product: two-component sensor kinase

essential: no

synonyms: yvqB

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]

[SW|Categories] containing this gene/protein

• [SW|protein modification], [SW|transcription factors and their control], [SW|heat shock proteins], [SW|membrane proteins], [SW|phosphoproteins]

This gene is a member of the following [SW|regulons]

• [SW|CssR regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,386,398 -> 3,387,753

The protein

Catalyzed reaction/ biological activity

• autophosphorylation, phosphorylation of [protein|search|CssR]

Paralogous protein(s)

• [protein|search|YkoH], [protein|search|KinE], [protein|search|YclK], [protein|search|YvrG]

[SW|Domains]

• two transmembrane segments, C-terminal histidine phosphotransferase domain

Modification

• autophosphorylation on a His residue

Effectors of protein activity

• the extracellular loop domain is required for signal perception [Pubmed|22307758]

[SW|Localization]

• cell membrane (according to Swiss-Prot)
• localized primarily at the division septum but also found in a punctate pattern with lower intensity throughout the cell cylinder [Pubmed|22307758]

[SW|Interactions]

• [protein|search|CssS] is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of [SW|interactions] [Pubmed|21630458]
• [protein|search|CssS]-[protein|search|CssR]

Expression and Regulation

Operon

• ''[protein|search|cssR]-[protein|search|cssS]'' [Pubmed|11555295]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|12270824]

Regulation

• expressed under conditions of secretion stress ([protein|search|CssR]) [Pubmed|12270824]

Regulatory mechanism

• [protein|search|CssR]: transcription activation [Pubmed|12270824]

Biological materials

Mutant

• BKE33010 ''cssS''::''erm trpC2'' is available from the Bacillus Genetic Stock Center

References

Reviews

• 27518094

Original Publications

• 10094672,17600057,21630458,17088376,12270824,11555295,19820159,21602801,21624103,22307758