SubtiBank SubtiBank
ykkD
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ykkD

putative guanidine exporter
locus
BSU_13100
pI
8.62
mw
11.19 kDa
protein length
105 aa Sequence Blast
gene length
318 bp Sequence Blast
function
export/ detoxification of guanidine
product
subunit of guanidine exporter
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.11|Other exporters]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    1,376,855 1,377,172

    The protein

    Protein family

  • paired small multidrug resistance protein family ([SW|PSMR family]) [Pubmed|17942072]
  • [SW|drug/metabolite transporter (DMT) superfamily] (according to UniProt)
  • [SW|Small multidrug resistance (SMR) (TC 2.A.7.1) family] (according to UniProt)
  • Structure

  • [PDB|3B5D] (from E. coli, 29% identity) [pubmed|18024586]
  • [SW|Localization]

  • cell membrane (according to UniProt)
  • Expression and Regulation

    Operons

    genes
    [gene|5FD89F65E481CDC33B10A58C12C3168B929917ED|ykkC]-[gene|5001019AD87FEF7D7A920D570C1053D476F7F20C|ykkD]
    description
    [Pubmed|10735877]

    regulatory mechanism

  • [protein|E9866855F0156859C45E98F3B385FE1263BB7EBC|YkkC riboswitch]: antitermination, [pubmed|28060483,27989440], in [regulon|E9866855F0156859C45E98F3B385FE1263BB7EBC|YkkC riboswitch regulon]
  • regulation

  • induced in the presence of guanidine ([SW|ykkC riboswitch]) [Pubmed|27989440]
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    Biological materials

    Mutant

  • MGNA-A748 (ykkD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/748 NBRP B. subtilis, Japan]
  • BKE13100 ([gene|5001019AD87FEF7D7A920D570C1053D476F7F20C|ykkD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE13100 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATAAACTGATCCAGTGCA, downstream forward: _UP4_TAAATTGATTTTTATCAAAT
  • BKK13100 ([gene|5001019AD87FEF7D7A920D570C1053D476F7F20C|ykkD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK13100 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATAAACTGATCCAGTGCA, downstream forward: _UP4_TAAATTGATTTTTATCAAAT
  • References

    Reviews

  • 17942072
  • Original publications

  • 10735877,21317561,27989440,27120414,18024586