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ykkD
putative guanidine exporter
function
export/ detoxification of guanidine
product
subunit of guanidine exporter
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.11|Other exporters][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
1,376,855 1,377,172
The protein
Protein family
paired small multidrug resistance protein family ([SW|PSMR family]) [Pubmed|17942072][SW|drug/metabolite transporter (DMT) superfamily] (according to UniProt)[SW|Small multidrug resistance (SMR) (TC 2.A.7.1) family] (according to UniProt)Structure
[PDB|3B5D] (from E. coli, 29% identity) [pubmed|18024586][SW|Localization]
cell membrane (according to UniProt)Expression and Regulation
Operons
genes
[gene|5FD89F65E481CDC33B10A58C12C3168B929917ED|ykkC]-[gene|5001019AD87FEF7D7A920D570C1053D476F7F20C|ykkD]
description
[Pubmed|10735877]
regulatory mechanism
[protein|E9866855F0156859C45E98F3B385FE1263BB7EBC|YkkC riboswitch]: antitermination, [pubmed|28060483,27989440], in [regulon|E9866855F0156859C45E98F3B385FE1263BB7EBC|YkkC riboswitch regulon]regulation
induced in the presence of guanidine ([SW|ykkC riboswitch]) [Pubmed|27989440]view in new tabBiological materials
Mutant
MGNA-A748 (ykkD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/748 NBRP B. subtilis, Japan]BKE13100 ([gene|5001019AD87FEF7D7A920D570C1053D476F7F20C|ykkD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE13100 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATAAACTGATCCAGTGCA, downstream forward: _UP4_TAAATTGATTTTTATCAAATBKK13100 ([gene|5001019AD87FEF7D7A920D570C1053D476F7F20C|ykkD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK13100 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATAAACTGATCCAGTGCA, downstream forward: _UP4_TAAATTGATTTTTATCAAATReferences
Reviews
Original publications
10735877,21317561,27989440,27120414,18024586