SubtiBank SubtiBank
ispC
The papers of the month are back! Check them out! Link here

ispC

1-deoxy-D-xylulose-5-phosphate reductoisomerase, second step in the MEP pathway of isoprenoid biosynthesis
locus
BSU16550
pI
5.80
mw
43.12 kDa
protein length
388 aa Sequence Blast
gene length
1164 bp Sequence Blast
function
MEP pathway of isoprenoid biosynthesis
product
1-deoxy-D-xylulose-5-phosphate reductoisomerase
essential
yes
ec
1.1.1.267
synonyms
yluB,dxr
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    1,722,871 → 1,724,022

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH (according to Swiss-Prot)

    • Protein family

  • DXR family (according to Swiss-Prot)

    • Structure

  • [PDB|1R0K] (from ''Zymomonas mobilis'', 45% identity) [Pubmed|15063313]

    • Expression and Regulation

    Operons

    genes
    [gene|58CDF08A8F05C0BC25EB6E400316F85FD0F307E5|ispC]-[gene|CB50289535EA537F63BADD459BD11AA7759A6658|rasP]-[gene|848570563D3C92A8E1E6AB4DA530388D8AE94E75|proS]-[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]
    description
    [Pubmed|22383849]
    view in new tab

    additional information

  • the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]

    • References

  • 17458547,15063313,21296950,23840410,26883633