SubtiBank SubtiBank
uxaC [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]
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uxaC [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

glucuronate isomerase (D-glucuronate, D-galacturonate)
locus
BSU12300
pI
5.17
mw
54.00 kDa
function
hexuronate utilization
product
glucuronate isomerase (D-glucuronate, D-galacturonate)
essential
no
ec
5.3.1.12
synonyms
yjmA

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate]
  • [SW|Categories] containing this gene/protein

  • [SW|utilization of specific carbon sources]
  • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon], [SW|ExuR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,300,450 -> 1,301,871

    The protein

    Catalyzed reaction/ biological activity

  • D-glucuronate = D-fructuronate (according to Swiss-Prot)
  • Protein family

  • uronate isomerase family (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|uxaC]-[protein|search|yjmB]-[protein|search|yjmC]-[protein|search|yjmD]-[protein|search|uxuA]-[protein|search|yjmF]-[protein|search|exuT]-[protein|search|exuR]-[protein|search|uxaB]-[protein|search|uxaA]'' [Pubmed|9882655]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|9882655]
  • Regulation

  • repressed by glucose ([protein|search|CcpA]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2]
  • induced by galacturonate ([protein|search|ExuR]) [Pubmed|9882655]
  • Regulatory mechanism

  • [protein|search|CcpA]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2]
  • [protein|search|ExuR]: reanscription repression in the absence of inducer [Pubmed|9882655]
  • References

  • 9579062,22900538,9579062,9882655,10666464