modulator of DegU activity, converts DegU-P from a repressor to an activator of the fla-che operon, enhances sigD transcription, controls the number of flagellar basal bodies, inactive pseudogene in strain 168
function
control of DegU activity
product
swarming motility protein
synonyms
swrA, swrAA, yvzD, ifm
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.3|Control of response regulators/ other][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.5|Additional chemotaxis signal transduction and regulatory proteins][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.5|Other proteins required for biofilm formation][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.4|Swarming][category|SW 6|Groups of genes] → [category|SW 6.10|Pseudogenes][SW|Categories] containing this gene/protein
[SW|biofilm formation], [SW|motility and chemotaxis], [SW|transcription factors and their control], [SW|pseudogenes]This gene is a member of the following [SW|regulons]
[SW|DegU regulon], [SW|SigD regulon]Gene
Coordinates on the chromosome (coding sequence)
3,621,618 -> 3,621,956
Phenotypes of a mutant
loss of swarming motility [Pubmed|12864845]The protein
Catalyzed reaction/ biological activity
interacts with the N-terminal domain of [protein|search|DegU] to control the activity of [protein|search|DegU] [Pubmed|22496484][SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|SwrA]-[protein|search|DegU]-P (N-terminal domain) [Pubmed|24386445,22496484][protein|search|SwrA]-[protein|search|SmiA] [Pubmed|25538299][protein|search|LonA]-[protein|search|SwrA] (degradation) [Pubmed|25538299]Expression and Regulation
Operon
''[SW|swrAA]-[protein|search|minJ]'' [Pubmed|16030230][SW|Sigma factor]
[protein|search|SigD] [Pubmed|18567663], [protein|search|SigA] [Pubmed|18567663]Regulatory mechanism
[protein|search|DegU]-P: transcription activation ([protein|search|SigA] promoter) [Pubmed|18567663]Additional information
SwrA levels are 3 ... 10-fold increased on solid medium as compared to liquid medium (due to [protein|search|LonA]/[protein|search|SmiA]-mediated degradation of SwrA in liquid medium) [PubMed|25538299]References
Reviews
Original publications
16091050,22773650,16357223,19389763,16030230,18567663,15066026,22496484,19389763,19749039,21278284,21602220,22329926,23190039,24386445,12864845,25538299,25843804 
