pyridoxal-5-phosphate synthase (glutaminase domain)
function
pyridoxal-5-phosphate biosynthesis
product
pyridoxal-5-phosphate synthase (glutaminase domain)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.12|Biosynthesis of pyridoxal phosphate][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors], [SW|sporulation/ other]This gene is a member of the following [SW|regulons]
[SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
19,968 -> 20,558
Phenotypes of a mutant
inactivation of ''[SW|pdxT]'' reduces [SW|sporulation] efficiency to 1.2% that of wild type cells; delayed entry into [SW|sporulation] [Pubmed|26735940]The protein
Protein family
glutamine amidotransferase pdxT/SNO family (according to Swiss-Prot)Structure
[PDB|2NV2] [protein|search|PdxS]-[protein|search|PdxT] complex [Pubmed|17159152][PDB|2NV0] (PdxT) [Pubmed|17159152][SW|Interactions]
[protein|search|PdxS]-[protein|search|PdxT] [Pubmed|25473090,14762015,16030023,17159152]Expression and Regulation
Operon
''[protein|search|pdxS]-[protein|search|pdxT]'' [Pubmed|22383849]Regulation
negatively controlled by [SW|Spo0A] [Pubmed|14651647]repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]Regulatory mechanism
[SW|Spo0A]: transcription repression [Pubmed|14651647]References
15911615,14762015,14651647,16030023,19152323,17159152,23832367,25473090,25568319,26490441,26735940, 16233205 
