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yugO [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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yugO [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

potassium channel protein (exporter)
locus
BSU31322
pI
7.00
mw
37.00 kDa
function
potassium exporter
product
potassium channel protein
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.1|Metal ion homeostasis (K, Na, Ca, Mg)] → [category|SW 1.3.1.3|Potassium uptake/ export]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.4|Regulation]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.5|Newly identified sporulation proteins (based on transcription profiling)]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|transporters/ other], [SW|metal ion homeostasis (K, Na, Ca, Mg)], [SW|biofilm formation], [SW|sporulation proteins], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|SinR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,218,854 -> 3,219,840

    Phenotypes of a mutant

  • reduced [SW|biofilm formation] (can be suppressed by inactivation of ''[protein|search|sinR]'') [Pubmed|23737939]
  • The protein

    [SW|Domains]

  • contains a [SW|RCK_N domain] (according to [http://www.uniprot.org/uniprot/?query=domain:RCK N-terminal domain* UniProt])
  • [SW|Localization]

  • inner spore membrane [Pubmed|26731423]
  • Additional information

  • potassium exporter activity of YugO is activated by glutamate limitation via the C-terminal domain [Pubmed|26503040]
  • Expression and Regulation

    Operon

  • ''[protein|search|mstX]-[protein|search|yugO]'' [Pubmed|23737939]
  • Regulation

  • repressed by [protein|search|SinR] [Pubmed|23737939]
  • Regulatory mechanism

  • [protein|search|SinR]: transcription repression [Pubmed|23737939]
  • Additional information

  • potassium exporter activity of YugO is activated by glutamate limitation via the C-terminal domain [Pubmed|26503040]
  • Biological materials

    Mutant

  • TMB92 (''yugO''::''tet''), available in [SW|Erhard Bremer]'s and [SW|Jörg Stülke]'s labs
  • GP2098 (''yugO''::''ermC''), available in [SW|Jörg Stülke]'s lab
  • References

    Reviews

  • 26503058
  • Original publications

  • 23737939,26503040,26731423,10617203