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hemE

uroporphyrinogen decarboxylase (uroporphyrinogen III)

locus: BSU_10120

pI: 5.26

mw: 39.49 kDa

protein length: 353 aa

gene length: 1062 bp

function: heme biosynthesis

product: uroporphyrinogen decarboxylase (uroporphyrinogen III)

essential: no

ec: 4.1.1.37

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

Gene

Coordinates: 1,086,117 1,087,178

The protein

Catalyzed reaction/ biological activity

• 4 H⁺ + uroporphyrinogen III --> 4 CO₂ + coproporphyrinogen III (according to UniProt)

Protein family

• uroporphyrinogen decarboxylase family (single member, according to UniProt)

Structure

• [PDB|2INF]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA|hemE]-[gene|E4C588EC93132CCBE4F40559F8A480A66A2D82D7|hemH]-[gene|7541AD7D06BC4CE30AD576562E0053CC1E25B4D6|hemY]
  description: [Pubmed|1459957]

Biological materials

Mutant

• BKE10120 ([gene|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA|hemE]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE10120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGATTTCCACCTTTCA, downstream forward: _UP4_TAAGCATATCTTTTGGTATC
• BKK10120 ([gene|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA|hemE]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK10120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGATTTCCACCTTTCA, downstream forward: _UP4_TAAGCATATCTTTTGGTATC

References

Reviews

• 28123057

Original Publications

• 17122346