SubtiBank SubtiBank
mdtR
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mdtR

transcription repressor of the multidrug-resistance [gene|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85|mdtR]-[gene|search|mdtP ]operon
locus
BSU_32870
pI
6.38
mw
17.26 kDa
protein length
155 aa Sequence Blast
gene length
468 bp Sequence Blast
function
regulation of the multidrug-resistance [gene|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85|mdtR]-[gene|search|mdtP ]operon
product
transcription repressor ([SW|MarR family])
essential
no
synonyms
yusO

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • Gene

    Coordinates
    3,374,492 3,374,959

    The protein

    Protein family

  • [SW|MarR family]
  • Structure

  • [PDB|1S3J]
  • Expression and Regulation

    Operons

    genes
    [gene|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85|mdtR]-[gene|45C61C1584A851676F15A2249F3F1092863C5AA5|mdtP]
    description
    [Pubmed|19286808]

    regulatory mechanism

  • [protein|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85|MdtR]: repression, [Pubmed|19286808], in [regulon|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85|MdtR regulon]
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    Biological materials

    Mutant

  • MGNA-B595 (yusO::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1594 NBRP B. subtilis, Japan]
  • GP1115 (spc), available in [SW|Jörg Stülke]'s lab
  • BKE32870 ([gene|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85|mdtR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE32870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCATTTCCCCTCTGT, downstream forward: _UP4_CAAAACATGAAAAGAGGAAA
  • BKK32870 ([gene|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85|mdtR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK32870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCATTTCCCCTCTGT, downstream forward: _UP4_CAAAACATGAAAAGAGGAAA
  • References

  • 19286808