SubtiBank SubtiBank
pncB
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pncB

nicotinate phosphoribosyltransferase
locus
BSU_31750
pI
5.09
mw
56.01 kDa
protein length
490 aa Sequence Blast
gene length
1473 bp Sequence Blast
function
NAD salvage
product
nicotinate phosphoribosyltransferase
essential
yes
ec
2.4.2.11
synonyms
yueK
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]
  • [category|SW 2|Metabolism] → [category|SW 2.7|Detoxification reactions]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    3,259,403 3,260,875

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • 5-phospho-α-D-ribose 1-diphosphate + ATP + H2O + nicotinate --> ADP + diphosphate + nicotinate β-D-ribonucleotide + phosphate (according to UniProt)

    • Protein family

  • NAPRTase family (single member, according to UniProt)

    • Structure

  • [PDB|2F7F] (from ''Enterococcus faecalis'', 61% identity)

    • Expression and Regulation

    Operons

    genes
    [gene|26430DCCEC263E7D03A3BBA4E7D636A250C3208B|pncA]-[gene|7CA7ADDBDDE46B0E6522704FD19C0BCF6FA9E058|pncB]
    description
    [Pubmed|22383849]
    view in new tab

    genes
    [gene|17F2619E74A1604E86ED94E1BEE683D49E437A6C|yueH]-[gene|3918D82756A64E86E96A21ACEB34B0CF992D662D|yueI]-[gene|26430DCCEC263E7D03A3BBA4E7D636A250C3208B|pncA]-[gene|7CA7ADDBDDE46B0E6522704FD19C0BCF6FA9E058|pncB]
    description
    [Pubmed|22383849]
    view in new tab

    Biological materials

    Mutant

  • MGNA-B562 (yueK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1561 NBRP B. subtilis, Japan]

    • References

  • 16199587,9274030