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cdsA

phosphatidate cytidylyltransferase

locus: BSU_16540

pI: 7.87

mw: 30.06 kDa

protein length: 269 aa

gene length: 810 bp

function: biosynthesis of phospholipids

product: phosphatidate cytidylyltransferase

essential: yes

ec: 2.7.7.41

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 1,722,000 1,722,809

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• 1,2-diacyl-sn-glycero-3-phosphate + CTP + H⁺ --> CDP-1,2-diacyl-sn-glycerol + diphosphate (according to UniProt)

Protein family

• CDS family (single member, according to UniProt)

Structure

• [PDB|4Q2G] (from ''Thermotoga maritima'', 36% identity) [Pubmed|24968740]

[SW|Localization]

• cell membrane at the septum [Pubmed|15743965,19820159]

Expression and Regulation

Operons

• genes: [gene|4A637EB9B400D30E5C6246D1E0EB5E6A30F38A16|uppS]-[gene|7E7F6BBA03C443A5AFA05A6D9352FEF1212A5AF6|cdsA]-[gene|58CDF08A8F05C0BC25EB6E400316F85FD0F307E5|ispC]-[gene|CB50289535EA537F63BADD459BD11AA7759A6658|rasP]-[gene|848570563D3C92A8E1E6AB4DA530388D8AE94E75|proS]-[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]
  description: [Pubmed|22383849]

additional information

• the mRNA is very stable (> 15 min) [pubmed|12884008]

References

• 12884008,15743965,19820159,24968740