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mscL [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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mscL [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

large conductance mechanosensitive channel protein, prevents selective release of cytoplasmic proteins in a hypotonic environment
locus
BSU36360
pI
4.65
mw
14.00 kDa
function
resistance to osmotic downshockglycine betaine export
product
large conductance mechanosensitive channel protein
essential
no
synonyms
ywpC

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.7|Coping with hypo-osmotic stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|coping with hypo-osmotic stress], [SW|membrane proteins]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,743,267 -> 3,743,659

    Phenotypes of a mutant

  • sensitive to osmotic downshock (> 0.5 M) during logarithmic growth [Pubmed|19252899]
  • The protein

    Protein family

  • mscL family (according to Swiss-Prot)
  • Structure

  • [PDB|3HZQ] (MscL of ''Staphylococcus aureus'') [Pubmed|19701184]
  • [SW|Localization]

  • cell membrane [Pubmed|19252899]
  • Expression and Regulation

    Operon

  • ''mscL'' [Pubmed|9353933]
  • Regulation

  • expressed in logarithmic phase [Pubmed|19252899]
  • Biological materials

    Mutant

  • 1A957 ( ''mscL''::''spec''), [Pubmed|18310427], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A957&Search=1A957 BGSC]
  • Labs working on this gene/protein

  • [SW|Jan Maarten van Dijl], Groningen, Netherlands
  • [SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]
  • References

    Reviews

  • 12626684,19727188,20825352,22685280,24258154
  • Original Publications

  • 17665170,18310427,19160392,16897034,19252899,19701184,9632260,19738010,9353933