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argD
acetylornithine transaminase
function
biosynthesis of arginine
product
acetylornithine transaminase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]Gene
Coordinates
1,198,099 → 1,199,256
The protein
Catalyzed reaction/ biological activity
2-oxoglutarate + N2-acetyl-L-ornithine --> L-glutamate + N-acetyl-L-glutamate 5-semialdehyde (according to UniProt)Protein family
[SW|Class-III pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)[SW|Cofactors]
PLP (according to UniProt)Structure
[PDB|2EH6] (from Aquifex aeolicus, 45% identity)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|62678D45FA1CB1B6AB801FB9F574DDE10DEE068D|argC]-[gene|0FF858E44B3C557EE2C8B3749A458F152E1C535C|argJ]-[gene|8321DF6EE5B84CC9A4A5DF670E8611F4D61EBC7E|argB]-[gene|7FA5502FE82D55EC176F68B74B24293EC9B7D4D7|argD]-[gene|4202EAE5D0B2A718382092423DD99E35FDE81218|carA]-[gene|7E6386F1949A6F46E4332BAB8F803742EB076AF0|carB]-[gene|11E7D77EF9439F817C10BF5D9671C5AE66AF06DC|argF]
description
[Pubmed|7511775]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|7511775], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|AhrC]: repression, [Pubmed|1312212], in [regulon|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|AhrC regulon][protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|24843172], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon][protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR]: regulation, [pubmed|30355672], in [regulon|F4097349A563503468A2A14F062AEAC532C7917A|YlxR regulon]regulation
repressed by arginine ([protein|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|AhrC]) [Pubmed|1312212]induced in the absence of [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR] [pubmed|30355672]view in new tabBiological materials
Mutant
BKE11220 (Δ[gene|7FA5502FE82D55EC176F68B74B24293EC9B7D4D7|argD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE11220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCTCATGAAACAGCCTCCTT, downstream forward: _UP4_TGATTTTTTTTCGATATAAABKK11220 (Δ[gene|7FA5502FE82D55EC176F68B74B24293EC9B7D4D7|argD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK11220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCTCATGAAACAGCCTCCTT, downstream forward: _UP4_TGATTTTTTTTCGATATAAAReferences
6096675,24843172,12107147,1312212,7511775