SubtiBank SubtiBank
cmpA
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cmpA

cortex morphogenic protein A, checkpoint protein, orchestrates spore coat and cortex morphogenesis
locus
G8J2-20
pI
0.00
mw
4.00 kDa
function
represses cortex assembly until the successful initiation of spore coat assembly
product
cortex morphogenic protein A, adapter protein targeting [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA] for degradation by [protein|search|ClpXP] upon spore envelope defects
synonyms

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.1|Spore coat proteins] → [category|SW 4.2.1.1.8|Not yet assigned]
  • Gene

    Coordinates
    525,021 → 528,076

    Phenotypes of a mutant

  • quicker progressing through the [SW|sporulation ] cycle [Pubmed|22463703]
  • overexpression of CmpA results in heat-sensitive sporulation [Pubmed|22463703,26387458], this can be suppressed by mutations in ''[gene|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]'' and ''[gene|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX]'' [Pubmed|26387458]
  • The protein

    Catalyzed reaction/ biological activity

  • orchestrates spore coat and cortex assembly [Pubmed|22463703]
  • represses cortex assembly until spore coat assembly successfully initiates [Pubmed|22463703]
  • [SW|Localization]

  • surface of the developing spore, this depends on a functional [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA] [Pubmed|22463703,26387458]
  • [SW|Interactions]

  • [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|ClpX]-[protein|85DE3CB6CDA61C141C6030367C0A13BB642160B9|CmpA] (for [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|ClpX]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|ClpP]-dependent degradation of [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA]) [Pubmed|26387458]
  • [protein|85DE3CB6CDA61C141C6030367C0A13BB642160B9|CmpA]-[protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA] (for [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|ClpX]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|ClpP]-dependent degradation of [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA]) [Pubmed|26387458]
  • Expression and Regulation

    Operons

    genes
    [gene|85DE3CB6CDA61C141C6030367C0A13BB642160B9|cmpA]
    description
    [Pubmed|22463703,20709900]

    sigma factors

  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|22463703], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]
  • regulatory mechanism

  • [protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID]: activation, [Pubmed|22463703], in [regulon|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID regulon]
  • regulation

  • expressed in mother cell during [SW|sporulation ] ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|22463703]
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    References

    Reviews

  • 27227299,26418292,28408070
  • Original publications

  • 22463703,26387458,20709900