SubtiBank SubtiBank
gamA [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]
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gamA [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

glucosamine-6-phosphate deaminase
locus
BSU02360
pI
5.79
mw
27.00 kDa
function
glucosamine utilization
product
glucosamine-6-phosphate deaminase
essential
no
synonyms
ybfT

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.3|Utilization of cell wall components]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.17|Utilization of amino sugars]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.3|Utilization of amino sugars]
  • [SW|Categories] containing this gene/protein

  • [SW|cell wall degradation/ turnover], [SW|utilization of specific carbon sources]
  • This gene is a member of the following [SW|regulons]

  • [SW|GamR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    256,823 -> 257,572

    Phenotypes of a mutant

  • no growth on glucosamine [Pubmed|23667565]
  • The protein

    Catalyzed reaction/ biological activity

  • d-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3 (according to Swiss-Prot)
  • Protein family

  • NagB subfamily (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|NagB]
  • Kinetic information

  • K(M): 3.0 mM [Pubmed|14343123]
  • Structure

  • [PDB|2BKX] (the structure of [protein|search|NagB], 50% identity) [Pubmed|15755726]
  • Expression and Regulation

    Operon

  • ''[protein|search|gamA]-[protein|search|gamP]'' [Pubmed|23667565]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|23667565]
  • Regulation

  • induced by N-acetylglucosamine [Pubmed|14343123]
  • induced by glucosamine ([protein|search|GamR]) [Pubmed|24673833,23667565]
  • Regulatory mechanism

  • [protein|search|GamR]: transcription repression [Pubmed|24673833,23667565]
  • References

  • 10627040,14343123,23667565,23876412,24673833,15755726