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panC
function
biosynthesis of coenzyme A
product
pantothenate synthase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.4|Biosynthesis of coenzyme A]Gene
Coordinates
2,352,977 2,353,837
The protein
Catalyzed reaction/ biological activity
(R)-pantoate + ATP + β-alanine --> (R)-pantothenate + AMP + diphosphate + H+ (according to UniProt)Protein family
pantothenate synthetase family (single member, according to UniProt)Structure
[PDB|2EJC] (from ''Thermotoga maritima'', 50% identity, 66% similarity)[SW|Localization]
cytoplasm (according to Swiss-Prot)Biological materials
Mutant
BKE22420 ([gene|8BE55434677F4EC3D6766C7163496CB1B659F57F|panC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE22420 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGAAATATCAGTAATCTGTC, downstream forward: _UP4_ATTCGAGAAATGGAGAGAATBKK22420 ([gene|8BE55434677F4EC3D6766C7163496CB1B659F57F|panC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK22420 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGAAATATCAGTAATCTGTC, downstream forward: _UP4_ATTCGAGAAATGGAGAGAAT