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yabR

similar to the C-terminal domain of E. coli polyribonucleotide phosphorylase and to four repeated domains at the N-terminus of E. coli ribosomal protein S1

locus: BSU_00630

pI: 10.34

mw: 14.05 kDa

protein length: 128 aa

gene length: 387 bp

function: unknown

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
• [category|SW 6|Groups of genes] → [category|SW 6.6|Poorly characterized/ putative enzymes]

Gene

Coordinates: 69,626 70,012

The protein

Protein family

• Peptidase U57 family (together with [protein|A46D07F8F56249A04C5F880120D19F00C9CAE112|YabG]) (according to UniProt)

Paralogous protein(s)

• [protein|B0908BB4B8B569A7A78BB0B84784FD4C427C598B|YugI]: 51% identity

[SW|Domains]

• [SW|S1 domain] (aa 4 ... 74) (according to the Interpro database)

Structure

• [PDB|2K4K] ([protein|B0908BB4B8B569A7A78BB0B84784FD4C427C598B|YugI], 51% identity from aa 3 ... 91) [pubmed|19152054]

Expression and Regulation

Operons

• genes: [gene|D6B1837075ECBEE1FEAC704DDB6795336092897F|yabM]-[gene|52D48F22CB53421EE30970D34B4861E2F8A5893D|yabN]-[gene|B0CB19A3E3E84E12BF42BB050394C8A059A89359|yabO]-[gene|035B5486A3887FC71ACC0A8FB43ED77DC44E12EA|yabP]-[gene|4DEDB27C0162409571AB4A1BB17CFE400764AE45|yabQ]-[gene|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC]-[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]
  description: [Pubmed|11283287]

  sigma factors

  • [protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM]: sigma factor, [Pubmed|18179421], in [regulon|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM regulon]
  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|15699190,11283287], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]
  • [protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|SigW]: sigma factor, [Pubmed|12207695], in [regulon|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|SigW regulon]
  • [protein|7024E4162A6D827069F882FDEACA696EBC05DD40|SigD]: sigma factor, [Pubmed|26577401], in [regulon|7024E4162A6D827069F882FDEACA696EBC05DD40|SigD regulon]
  • [protein|E77364F274A520FCCA9F5C9504E317B047BA29E6|SigX]: sigma factor, [Pubmed|12207695], in [regulon|E77364F274A520FCCA9F5C9504E317B047BA29E6|SigX regulon]

  regulation

  • expressed during sporulation ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]) [Pubmed|11283287]

• genes: [gene|035B5486A3887FC71ACC0A8FB43ED77DC44E12EA|yabP]-[gene|4DEDB27C0162409571AB4A1BB17CFE400764AE45|yabQ]-[gene|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC]-[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]
  description: [Pubmed|11283287]

  regulation

  • expressed during sporulation ([protein|search|SigE]) [Pubmed|11283287]

  additional information

  • there are about 50,000 molecules of DivIC per cell [http://www.ncbi.nlm.nih.gov/sites/entrez/9426141 PubMed]

• genes: [gene|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC]-[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]
  description: [Pubmed|11283287]

  regulation

  • expressed during sporulation ([protein|search|SigE]) [Pubmed|11283287] and under stress conditions

  additional information

  • there are about 50,000 molecules of DivIC per cell [http://www.ncbi.nlm.nih.gov/sites/entrez/9426141 PubMed]

Biological materials

Mutant

• MGNA-B919 (yabR::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1918 NBRP B. subtilis, Japan]
• BKE00630 ([gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE00630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAAAAAAGTGCTCCTCC, downstream forward: _UP4_TAACTTGCTGCTTTCTATAA
• BKK00630 ([gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK00630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAAAAAAGTGCTCCTCC, downstream forward: _UP4_TAACTTGCTGCTTTCTATAA

References

• 11283287,12207695,19152054