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dCMP deaminase, late competence protein required for DNA binding and uptake, recruitment of [protein|41DFEF8A6BC7E34A6681C26D92F2B08DC120A957|ComGA] to the cell pole
function
recruitment of [protein|41DFEF8A6BC7E34A6681C26D92F2B08DC120A957|ComGA] to the cell pole
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]Gene
Coordinates
2,639,877 2,640,446
The protein
Catalyzed reaction/ biological activity
recruitment of [protein|41DFEF8A6BC7E34A6681C26D92F2B08DC120A957|ComGA] to the cell pole [pubmed|31954084]deoxycytidylate monophosphate (dCMP) deaminase [pubmed|31954084]Protein family
[SW|Cytidine and deoxycytidylate deaminase family] (according to UniProt)[SW|Domains]
[SW|CMP/dCMP-type deaminase domain] (aa 5–132) (according to UniProt)Structure
[PDB|2HVV] (from Streptococcus mutans, 50% identity) [pubmed|18255096][SW|Localization]
localizes to one or both cell poles [Pubmed|31954084,21278288]Expression and Regulation
Operons
genes
[gene|788725411B2E741103603373E43441FD036E1BA0|comEA]-[gene|954359717E15DFC106A9D8111C6637E46B16F8C9|comEB]-[gene|363C6FE07C5E56FDE6BEC6ACFBA1A5535F0F64AC|comEC]
description
[Pubmed|7968523,19028902]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|7968523], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK]: activation, [Pubmed|8196543], in [regulon|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK regulon]view in new tabOther regulations
[protein|F21A75744FA0B25D5A251CB57E7A7DC6ABFF1DC7|ComN]: post-translation control, Biological materials
Mutant
BKE25580 ([gene|954359717E15DFC106A9D8111C6637E46B16F8C9|comEB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE25580 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTTGTTCCCTCCAAATG, downstream forward: _UP4_CTTTTCACGAGCTACGTGTGBKK25580 ([gene|954359717E15DFC106A9D8111C6637E46B16F8C9|comEB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK25580 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTTGTTCCCTCCAAATG, downstream forward: _UP4_CTTTTCACGAGCTACGTGTGReferences
11814663,7968523,21278288,19028902,18255096,31954084