SubtiBank SubtiBank
thiD [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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thiD [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase
locus
BSU11710
pI
5.71
mw
28.00 kDa
function
biosynthesis of thiamine pyrophosphate (TPP)
product
4-amino-5-hydroxymethyl-2-methylpyrimidine
pyrophosphate kinase
essential
no
ec
2.7.1.49
synonyms
yjbV
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]

    • This gene is a member of the following [SW|regulons]

  • [SW|Thi-box]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,246,837 -> 1,247,652

    The protein

    Paralogous protein(s)

  • [protein|search|PdxK]

    • Structure

  • [PDB|2I5B] [Pubmed|16978644]

    • Expression and Regulation

    Operon

  • ''[protein|search|tenA]-[protein|search|tenI]-[protein|search|thiO]-[protein|search|thiS]-[protein|search|thiG]-[protein|search|thiF]-[protein|search|thiD]'' [Pubmed|1898926]

    • Regulation

  • repressed by thiamine ([protein|search|Thi-box]) [Pubmed|16356850]

    • Regulatory mechanism

  • [protein|search|Thi-box]: [SW|RNA switch] [Pubmed|16356850]

    • References

    Reviews

  • 19348578,10382260

    • Original publications

  • 14973012,16978644