SubtiBank SubtiBank
ydiO
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ydiO

similar to DNA-3-methyladenine glycosidase II
locus
BSU_06060
pI
7.66
mw
48.75 kDa
protein length
427 aa Sequence Blast
gene length
1284 bp Sequence Blast
function
BsuM DNA modification
product
unknown
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.4|DNA restriction/ modification]
  • [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.5|Prophage 3]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    655,223 656,506

    Phenotypes of a mutant

  • essential [Pubmed|12682299], mutation is only possible in a ''[gene|4BD4CFB10700907DF1BBF3C9CFACAF573588E85F|ydiR]'', ''[gene|A8C606348C8C6FC3BB9786C06C9BFE9D3519A041|ydiS]'', or ''[gene|D36B91B3C8EAFEB80A7395C62A50A5F80B8CC5C5|ydjA]'' background (''i. e.'', in the absence of the BsuM DNA restriction system) [Pubmed|11751814]
  • The protein

    Catalyzed reaction/ biological activity

  • 2'-deoxycytidine in DNA + S-adenosyl-L-methionine --> 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine (according to UniProt)
  • Protein family

  • [SW|Methyltransferase superfamily] (according to UniProt)
  • [SW|class I-like SAM-binding methyltransferase superfamily] (according to UniProt)
  • [SW|Domains]

  • SAM-dependent MTase C5-type domain (aa 84-427) (according to UniProt)
  • Structure

  • [PDB|3G7U] (from E. coli phage, 28% identity)
  • Expression and Regulation

    Operons

    genes
    [gene|9EE25F97B2C6240E31BA1D5EEE9DA2D7940C9637|ydiO]-[gene|CEA337DD4C7DFC22247FDA7FA1E71356FB819C77|ydiP]
    description
    [Pubmed|11751814]

    regulatory mechanism

  • [protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]: repression, [Pubmed|16267290], in [regulon|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA regulon]
  • regulation

  • induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]
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    References

  • 16267290,11751814,22092861