SubtiBank SubtiBank
thyB [Wed Dec 09 2015 11:16:56 GMT+0100 (CET)]
SAVE THE DATE! 21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.

thyB [Wed Dec 09 2015 11:16:56 GMT+0100 (CET)]

thymidylate synthase B
locus
BSU21820
pI
6.00
mw
30.00 kDa
function
biosynthesis of thymidine nucleotides
product
thymidylate synthase B
essential
no
ec
2.1.1.45
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides], [SW|phosphoproteins]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,297,106 -> 2,297,900

    The protein

    Catalyzed reaction/ biological activity

  • 5,10-methylenetetrahydrofolate dUMP = dihydrofolate dTMP (according to Swiss-Prot)
  • Paralogous protein(s)

  • [SW|ThyA]
  • Modification

  • phosphorylated on Arg-102 [Pubmed|22517742]
  • [SW|Interactions]

  • [protein|search|DfrA]-[protein|search|ThyB]
  • Expression and Regulation

    Operon

  • ''[protein|search|thyB]-[protein|search|dfrA]'' [Pubmed|2840350]
  • Regulation

  • weak induction in the presence of glucose ([protein|search|CcpN]) [Pubmed|19732150]
  • Regulatory mechanism

  • [protein|search|CcpN]: weak transcription activation [Pubmed|19732150]
  • References

  • 418407,19732150,2840350,22517742