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nifS [Mon Aug 31 2015 13:56:02 GMT+0200 (CEST)]
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nifS [Mon Aug 31 2015 13:56:02 GMT+0200 (CEST)]

cysteine desulfurase, required for NAD biosynthesis
locus
BSU27880
pI
6.43
mw
43.00 kDa
function
NAD biosynthesis
product
cysteine desulfurase
essential
no
ec
2.8.1.7
synonyms
iscS
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]
    • syns
    iscS

    [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]

    • This gene is a member of the following [SW|regulons]

  • [SW|NadR regulon]

    • The protein

    Catalyzed reaction/ biological activity

  • L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine (according to Swiss-Prot)

    • Protein family

  • NifS/iscS subfamily (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|YrvO], [protein|search|NifZ], [protein|search|SufS], [protein|search|YcbU]

    • [SW|Cofactors]

  • pyridoxalphosphate [Pubmed|25447671]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|nifS]-[protein|search|nadR]'' [Pubmed|8444804]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8444804]

    • Regulation

  • repressed in the presence of nicotinic acid ([protein|search|NadR]) [Pubmed|8444804,16199587]

    • Regulatory mechanism

  • [protein|search|NadR]: transcription repression [Pubmed|8444804,16199587]

    • References

    Reviews

  • 25447671

    • Original publications

  • 8444804,16199587,16199587,14567704