SubtiBank SubtiBank
psdB
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psdB

[SW|ABC transporter] (permease) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin
locus
BSU_34690
pI
9.80
mw
73.22 kDa
protein length
646 aa Sequence Blast
gene length
1941 bp Sequence Blast
function
export of toxic peptides
product
[SW|ABC transporter] (permease)
essential
no
synonyms
yvcS

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.2|Exporters] → [category|SW 1.2.1.2.3|Export of peptides]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    3,563,581 3,565,521

    The protein

    Protein family

  • [SW|ABC-4 integral membrane protein family] (according to UniProt)
  • Paralogous protein(s)

  • [protein|4423383A3F6DAFDFA210F4BEEF7D8CBEC674DCEA|YxdM]
  • [SW|Localization]

  • cell membrane (according to UniProt)
  • Expression and Regulation

    Operons

    genes
    [gene|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]-[gene|A9525886E911164BDFF0A55DA9F5FDD1C1B7A3B6|psdS]-[gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]-[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]
    description
    [Pubmed|21078927]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|21078927], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [protein|985E7F25C809AA5DF372101E64960DF704EED53F|PsdR]: activation, [Pubmed|21078927], in [regulon|985E7F25C809AA5DF372101E64960DF704EED53F|PsdR regulon]
  • regulation

  • ''[protein|search|psdA]'': induced by nisin, gallidermin ([protein|search|PsdR]) [Pubmed|21078927]
  • view in new tab

    genes
    [gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]-[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]
    description
    [Pubmed|18394148]

    regulation

  • ''[protein|search|psdA]'': induced by nisin, gallidermin ([protein|search|PsdR]) [Pubmed|21078927]
  • view in new tab

    Biological materials

    Mutant

  • MGNA-B634 (yvcS::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1633 NBRP B. subtilis, Japan]
  • BKE34690 ([gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE34690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCGTTGCAGATTCCCAAGAA, downstream forward: _UP4_TAATATGAAATCCGGTCTGT
  • BKK34690 ([gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK34690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCGTTGCAGATTCCCAAGAA, downstream forward: _UP4_TAATATGAAATCCGGTCTGT
  • References

  • 18394148,10092453,21283517